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Literature DB >> 6870814

Hormonal stimulation of mitochondrial glutaminase. Effects of vasopressin, angiotensin II, adrenaline and glucagon.

Abstract

Adrenaline (through alpha 1-adrenoceptors), vasopressin and angiotensin II stimulate mitochondrial glutaminase activity. This stimulation probably contributes to the ureogenic effect of these hormones. The activity of the enzyme is sensitive to Ca2+ depletion. A role of Ca2+ in hormonal modulation of glutaminase activity is suggested.

Entities: Chemical Gene

Mesh：

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Year: 1983 PMID： 6870814 PMCID： PMC1154314 DOI： 10.1042/bj2100957

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.

Authors: P F Blackmore; B P Hughes; E A Shuman; J H Exton
Journal: J Biol Chem Date: 1982-01-10 Impact factor: 5.157

2. The stimulation of glutamine hydrolysis in isolated rat liver mitochondria by Mg2+ depletion and hypo-osmotic incubation conditions.

Authors: S K Joseph; J D McGivan; A J Meijer
Journal: Biochem J Date: 1981-01-15 Impact factor: 3.857

3. Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

Authors: M E Tolbert; A C White; K Aspry; J Cutts; J N Fain
Journal: J Biol Chem Date: 1980-03-10 Impact factor: 5.157

4. The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production.

Authors: M A Titheradge; R C Haynes
Journal: Arch Biochem Biophys Date: 1980-04-15 Impact factor: 4.013

5. Ferroactivator and the regulation of gluconeogenesis.

Authors: H A Lardy; M L Merryfield
Journal: Curr Top Cell Regul Date: 1981

6. Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with alpha-adrenergic agonists and with glucagon.

Authors: W M Taylor; V Prpić; J H Exton; F L Bygrave
Journal: Biochem J Date: 1980-05-15 Impact factor: 3.857

7. The effects of ammonium chloride and bicarbonate on the activity of glutaminase in isolated liver mitochondria.

Authors: S K Joseph; J D McGivan
Journal: Biochem J Date: 1978-12-15 Impact factor: 3.857

8. The relationship between intramitochondrial N-acetylglutamate and activity of carbamoyl-phosphate synthetase (ammonia). The effect of glucagon.

Authors: H E Hensgens; A J Verhoeven; A J Meijer
Journal: Eur J Biochem Date: 1980

Hormonal stimulation of mitochondrial glutaminase. Effects of vasopressin, angiotensin II, adrenaline and glucagon.

1. alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.

2. The stimulation of glutamine hydrolysis in isolated rat liver mitochondria by Mg2+ depletion and hypo-osmotic incubation conditions.

3. Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

4. The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production.

5. Ferroactivator and the regulation of gluconeogenesis.

6. Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with alpha-adrenergic agonists and with glucagon.

7. The effects of ammonium chloride and bicarbonate on the activity of glutaminase in isolated liver mitochondria.

8. The relationship between intramitochondrial N-acetylglutamate and activity of carbamoyl-phosphate synthetase (ammonia). The effect of glucagon.

9. Alpha 1-adrenoceptor activation stimulates ureogenesis in rat hepatocytes.

10. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Review 1. Nitrogen metabolism in liver: structural and functional organization and physiological relevance.

2. The ornithine requirement of urea synthesis. Formation of ornithine from glutamine in hepatocytes.

3. Alpha-adrenergic stimulation of glutamine metabolism in isolated rat hepatocytes.

4. Influence of phospholipids on the activity of phosphate-dependent glutaminase in extracts of rat liver mitochondria.

5. Partial purification and properties of rat liver glutaminase.

Review 6. Role of phosphate-activated glutaminase in the pathogenesis of hepatic encephalopathy.

7. Effect of phenylephrine on glutamate and glutamine metabolism in isolated perfused rat liver.

8. Is N-acetylglutamate a short-term regulator of urea synthesis?

9. Rapid activation of hepatic glutaminase in rats fed on a single high-protein meal.

10. Activation of hepatic glutaminase by spermine.