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Literature DB >> 6721845

Is N-acetylglutamate a short-term regulator of urea synthesis?

Abstract

A method is described for determining N-acetylglutamate as glutamate. N-Acetylglutamate content of hepatocytes from 48 h-starved rats is high. It shows no parallelism with rates of urea synthesis from glutamine. We question its accepted function as a short-term regulator of urea synthesis.

Entities: Chemical Species

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Year: 1984 PMID： 6721845 PMCID： PMC1153434 DOI： 10.1042/bj2180991

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

20 in total

1. Biosynthetic capacity of hepatocytes after storage at 4 degrees C.

Authors: R Farrell; P Lund
Journal: Biosci Rep Date: 1983-06 Impact factor: 3.840

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Authors: A WOLLENBERGER; O RISTAU; G SCHOFFA
Journal: Pflugers Arch Gesamte Physiol Menschen Tiere Date: 1960

3. Role of acetylglutamate in ureotelism. I. Occurrence and biosynthesis of acetylglutamate in mouse and rat tissues.

Authors: K Shigesada; M Tatibana
Journal: J Biol Chem Date: 1971-09-25 Impact factor: 5.157

4. Influence of phospholipids on the activity of phosphate-dependent glutaminase in extracts of rat liver mitochondria.

Authors: J D McGivan; N M Bradford
Journal: Biochem J Date: 1983-08-15 Impact factor: 3.857

5. Turnover of N-acetylglutamate in isolated rat hepatocytes.

Authors: A J Meijer; G M Van Woerkom
Journal: Biochim Biophys Acta Date: 1982-11-17

6. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver.

Authors: D Häussinger
Journal: Eur J Biochem Date: 1983-06-15

7. Measurement of the intramitochondrial volume in hepatocytes without cell disruption and its elevation by hormones and valinomycin.

Authors: P T Quinlan; A P Thomas; A E Armston; A P Halestrap
Journal: Biochem J Date: 1983-08-15 Impact factor: 3.857

8. Properties of carbamoyl-phosphate synthetase (ammonia) in rat-liver mitochondria made permeable with toluene.

Authors: C Lof; M Cohen; L P Vermeulen; C W van Roermund; R J Wanders; A J Meijer
Journal: Eur J Biochem Date: 1983-09-15

9. The effect of lysine on gluconeogenesis from lactate in rat hepatocytes.

Authors: N W Cornell; P Lund; H A Krebs
Journal: Biochem J Date: 1974-08 Impact factor: 3.857

10. The regulation of carbamoyl phosphate synthase activity in rat liver mitochondria.

Authors: J D McGivan; N M Bradford; J Mendes-Mourão
Journal: Biochem J Date: 1976-02-15 Impact factor: 3.857

9 in total

1. Effect of level of dietary protein on arginine-stimulated citrulline synthesis. Correlation with mitochondrial N-acetylglutamate concentrations.

Authors: B H Morimoto; J F Brady; D E Atkinson
Journal: Biochem J Date: 1990-12-15 Impact factor: 3.857

2. New kinetic parameters for rat liver arginase measured at near-physiological steady-state concentrations of arginine and Mn2+.

Authors: S Maggini; F B Stoecklin-Tschan; S Mörikofer-Zwez; P Walter
Journal: Biochem J Date: 1992-05-01 Impact factor: 3.857

3. The ornithine requirement of urea synthesis. Formation of ornithine from glutamine in hepatocytes.

Authors: P Lund; D Wiggins
Journal: Biochem J Date: 1986-11-01 Impact factor: 3.857

4. N-acetylglutamate and urea synthesis.

Authors: A J Meijer; A J Verhoeven
Journal: Biochem J Date: 1984-10-15 Impact factor: 3.857

5. Human hepatic N-acetylglutamate content and N-acetylglutamate synthase activity. Determination by stable isotope dilution.

Authors: M Tuchman; R A Holzknecht
Journal: Biochem J Date: 1990-10-15 Impact factor: 3.857