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Literature DB >> 6615486

Influence of phospholipids on the activity of phosphate-dependent glutaminase in extracts of rat liver mitochondria.

Abstract

Liver glutaminase can be solubilized from frozen-and-thawed mitochondria by treatment with phospholipase A2. Solubilization by this technique markedly changes the kinetic properties of the enzyme. The properties of the membrane-bound form of the enzyme are partially restored by adding phosphatidylcholine or phosphatidylethanolamine to the phospholipase extract. It is concluded that the kinetic properties of liver glutaminase are a function of the interaction of this enzyme with membrane phospholipids.

Entities: Chemical Gene Species

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Year: 1983 PMID： 6615486 PMCID： PMC1152294 DOI： 10.1042/bj2140649

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

5 in total

1. THE INTERACTION OF UNCOUPLING PHENOLS WITH MITOCHONDRIA AND WITH MITOCHONDRIAL PROTEIN.

Authors: E C WEINBACH; J GARBUS
Journal: J Biol Chem Date: 1965-04 Impact factor: 5.157

2. The stimulation of glutamine hydrolysis in isolated rat liver mitochondria by Mg2+ depletion and hypo-osmotic incubation conditions.

Authors: S K Joseph; J D McGivan; A J Meijer
Journal: Biochem J Date: 1981-01-15 Impact factor: 3.857

3 in total

Influence of phospholipids on the activity of phosphate-dependent glutaminase in extracts of rat liver mitochondria.

1. THE INTERACTION OF UNCOUPLING PHENOLS WITH MITOCHONDRIA AND WITH MITOCHONDRIAL PROTEIN.

2. The stimulation of glutamine hydrolysis in isolated rat liver mitochondria by Mg2+ depletion and hypo-osmotic incubation conditions.

3. Hormonal stimulation of mitochondrial glutaminase. Effects of vasopressin, angiotensin II, adrenaline and glucagon.

4. Localization and some properties of phosphate-dependent glutaminase in disrupted liver mitochondria.

5. Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride.

1. Partial purification and properties of rat liver glutaminase.

2. Is N-acetylglutamate a short-term regulator of urea synthesis?

3. Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells.