Literature DB >> 6862020

Rapid purification of bovine kidney branched-chain 2-oxoacid dehydrogenase complex containing endogenous kinase activity.

R Lawson, K G Cook, S J Yeaman.   

Abstract

Branched-chain 2-oxoacid dehydrogenase complex has been purified to near homogeneity by a simple, rapid procedure. The final product contains endogenous kinase activity capable of phosphorylating and inactivating the complex. Phosphorylation continues after complete inactivation, indicating the possibility of several phosphorylatable sites.

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Year:  1983        PMID： 6862020     DOI： 10.1016/0014-5793(83)81115-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  A potent, heat-stable protein inhibitor of [branched-chain alpha-keto acid dehydrogenase]-phosphatase from bovine kidney mitochondria.

Authors:  Z Damuni; J S Humphreys; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

2.  Oxidative decarboxylation of 4-methylthio-2-oxobutyrate by branched-chain 2-oxo acid dehydrogenase complex.

Authors:  S M Jones; S J Yeaman
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

3.  Resolution and reconstitution of bovine kidney branched-chain 2-oxo acid dehydrogenase complex.

Authors:  K G Cook; A P Bradford; S J Yeaman
Journal:  Biochem J       Date:  1985-02-01       Impact factor: 3.857

4.  A structural abnormality of E1 component of the branched-chain alpha-keto acid dehydrogenase complex in maple syrup urine disease.

Authors:  Y Indo; A Kitano; I Akaboshi; F Endo; I Matsuda
Journal:  J Inherit Metab Dis       Date:  1987       Impact factor: 4.982

5.  Low immunogenicity of the common lipoamide dehydrogenase subunit (E3) of mammalian pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multienzyme complexes.

Authors:  O L De Marcucci; A Hunter; J G Lindsay
Journal:  Biochem J       Date:  1985-03-01       Impact factor: 3.857

6.  Phosphorylation of branched-chain 2-oxo acid dehydrogenase complex in isolated adipocytes. Effects of 2-oxo acids.

Authors:  S M Jones; S J Yeaman
Journal:  Biochem J       Date:  1986-05-15       Impact factor: 3.857

7.  A study of the metabolism of [U-14C]3-methyl-2-oxopentanoate by rat liver mitochondria using h.p.l.c. with continuous on-line monitoring of radioactive intact acyl-coenzyme A intermediates.

Authors:  A G Causey; B Middleton; K Bartlett
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

8.  Altered kinetic properties of the branched-chain alpha-keto acid dehydrogenase complex due to mutation of the beta-subunit of the branched-chain alpha-keto acid decarboxylase (E1) component in lymphoblastoid cells derived from patients with maple syrup urine disease.

Authors:  Y Indo; A Kitano; F Endo; I Akaboshi; I Matsuda
Journal:  J Clin Invest       Date:  1987-07       Impact factor: 14.808

9.  Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.

Authors:  S P Fussey; J R Guest; O F James; M F Bassendine; S J Yeaman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

10.  Purification and properties of branched-chain alpha-keto acid dehydrogenase phosphatase from bovine kidney.

Authors:  Z Damuni; M L Merryfield; J S Humphreys; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205
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