Literature DB >> 6856460

Specifically alkylated DNA fragments. Synthesis and physical characterization of d[CGC(O6Me)GCG] and d[CGT(O6Me)GCG].

S Kuzmich, L A Marky, R A Jones.   

Abstract

Two hexamer DNA fragments containing a carcinogenic modified base, O6-methyl guanine, have been synthesized by a solid-phase phosphotriester method, in which the unmodified guanine residues present were O6 protected with the 4-nitrophenylethyl group. These two alkylated oligonucleotides were found to have similar Tm's about 40 degrees lower than the unmodified parent compound, d(CG)3. Moreover, the presence of the (O6Me)G appears to inhibit the B leads to Z transition, as determined by CD spectroscopy.

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Year:  1983        PMID： 6856460      PMCID： PMC325971          DOI： 10.1093/nar/11.10.3393

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  14 in total

1.  The properties of O 6 -methylguanine in templates for RNA polymerase.

Authors:  L L Gerchman; D B Ludlum
Journal:  Biochim Biophys Acta       Date:  1973-05-10

2.  Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors:  F M Pohl; T M Jovin
Journal:  J Mol Biol       Date:  1972-06-28       Impact factor: 5.469

3.  Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides.

Authors:  A Loveless
Journal:  Nature       Date:  1969-07-12       Impact factor: 49.962

4.  Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Authors:  A H Wang; G J Quigley; F J Kolpak; J L Crawford; J H van Boom; G van der Marel; A Rich
Journal:  Nature       Date:  1979-12-13       Impact factor: 49.962

5.  Repair of O6-methylguanine in adapted Escherichia coli.

Authors:  P F Schendel; P E Robins
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

Review 6.  The origin of human cancers.

Authors:  J Cairns
Journal:  Nature       Date:  1981-01-29       Impact factor: 49.962

7.  Mismatch correction at O6-methylguanine residues in E. coli DNA.

Authors:  P Karran; M G Marinus
Journal:  Nature       Date:  1982-04-29       Impact factor: 49.962

8.  Chemical synthesis of tridecanucleoside dodecaphosphate sequence of SV40 DNA.

Authors:  J B Chattopadhyaya; C B Reese
Journal:  Nucleic Acids Res       Date:  1980-05-10       Impact factor: 16.971

9.  Synthesis and properties of O6-methyldeoxyguanylic acid and its copolymers with deoxycytidylic acid.

Authors:  J R Mehta; D B Ludlum
Journal:  Biochim Biophys Acta       Date:  1978-12-21

10.  Solid phase synthesis of polynucleotides. VI. Further studies on polystyrene copolymers for the solid support.

Authors:  H Ito; Y Ike; S Ikuta; K Itakura
Journal:  Nucleic Acids Res       Date:  1982-03-11       Impact factor: 16.971
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  10 in total

1.  High-resolution structure of a mutagenic lesion in DNA.

Authors:  G A Leonard; J Thomson; W P Watson; T Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  DNA stability in the gas versus solution phases: a systematic study of thirty-one duplexes with varying length, sequence, and charge level.

Authors:  Su Pan; Xuejun Sun; Jeehiun K Lee
Journal:  J Am Soc Mass Spectrom       Date:  2006-08-17       Impact factor: 3.109

3.  Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase.

Authors:  Francis P McManus; Qingming Fang; Jason D M Booth; Anne M Noronha; Anthony E Pegg; Christopher J Wilds
Journal:  Org Biomol Chem       Date:  2010-08-13       Impact factor: 3.876

4.  Guanine modification during chemical DNA synthesis.

Authors:  J S Eadie; D S Davidson
Journal:  Nucleic Acids Res       Date:  1987-10-26       Impact factor: 16.971

5.  Use of oligonucleotides containing ethenoadenine to study the repair of this DNA lesion. Determination of individual and collective repair activities.

Authors:  F Oesch; C M Weiss; S Klein
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

6.  uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174.

Authors:  R W Chambers; E Sledziewska-Gojska; S Hirani-Hojatti; H Borowy-Borowski
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

7.  B- to Z-DNA transition probed by oligonucleotides containing methylphosphonates.

Authors:  L Callahan; F S Han; W Watt; D Duchamp; F J Kézdy; K Agarwal
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

8.  Effect of 3' flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used.

Authors:  B Singer; F Chavez; M F Goodman; J M Essigmann; M K Dosanjh
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

9.  In vivo effect of DNA repair on the transition frequency produced from a single O6-methyl- or O6-n-butyl-guanine in a T:G base pair.

Authors:  R W Chambers; E Sledziewska-Gojska; S Hirani-Hojatti
Journal:  Mol Gen Genet       Date:  1988-08

10.  Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.

Authors:  H Kataoka; J Hall; P Karran
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598
  10 in total

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