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Literature DB >> 6852828

A new inducible fragile site on chromosome 3(p14.2) in human lymphocytes.

Abstract

A fragile site on chromosome 3(p14.2) was found in lymphocytes of two unrelated patients. Expression of the trait with 6%-18% affected cells could only be demonstrated under culture conditions favouring a low concentration of folic acid. Family investigations proved the maternal transmission of the cytologic marker in one case. In contrast to other fragile sites chromatid type aberrations predominated.

Entities: Chemical Gene Species

Mesh：

Substances：
Folic Acid

Year: 1983 PMID： 6852828 DOI： 10.1007/bf00284670

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

11 in total

1. Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects.

Authors: S Aymé; J F Mattei; M G Mattei; Y Aurran; F Giraud
Journal: Hum Genet Date: 1976-02-29 Impact factor: 4.132

2. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

3. Inherited constriction fragility of chromosome 2.

Authors: M A Ferguson-Smith
Journal: Ann Genet Date: 1973-03

4. Constitutional chromosomal breakage.

Authors: F Giraud; S Ayme; J F Mattei; M G Mattei
Journal: Hum Genet Date: 1976-10-28 Impact factor: 4.132

Review 5. The fragile X chromosome: current methods.

Authors: F Hecht; P B Jacky; G R Sutherland
Journal: Am J Med Genet Date: 1982-04

6. Expression of fra(X)(q28) is suppressed in man-mouse hybrid cells.

Authors: R D Wegner; B Geiseler; K Sperling
Journal: Hum Genet Date: 1982 Impact factor: 4.132

7. The characterization of high-resolution G-banded chromosomes of man.

Authors: J J Yunis; J R Sawyer; D W Ball
Journal: Chromosoma Date: 1978-08-14 Impact factor: 4.316

8. Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1982-05 Impact factor: 11.025

9. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

Authors:
Journal: Cytogenet Cell Genet Date: 1981

10. Further delineation of X-linked mental retardation.

Authors: D S Herbst; H G Dunn; F J Dill; D K Kalousek; L W Krywaniuk
Journal: Hum Genet Date: 1981 Impact factor: 4.132

9 in total

1. Inducible fragile site on chromosome 3.

Authors: A Markkanen; S Knuutila; A de la Chapelle
Journal: Hum Genet Date: 1983 Impact factor: 4.132

2. Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites.

Authors: G Barbi; P Steinbach; W Vogel
Journal: Hum Genet Date: 1984 Impact factor: 4.132

A new inducible fragile site on chromosome 3(p14.2) in human lymphocytes.

1. Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects.

2. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

3. Inherited constriction fragility of chromosome 2.

4. Constitutional chromosomal breakage.

Review 5. The fragile X chromosome: current methods.

6. Expression of fra(X)(q28) is suppressed in man-mouse hybrid cells.

7. The characterization of high-resolution G-banded chromosomes of man.

8. Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites.

9. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

10. Further delineation of X-linked mental retardation.

1. Inducible fragile site on chromosome 3.

2. Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites.

3. Autosomal lesions versus fragile sites.

4. The inducible fragile site on chromosome 3.

5. Autosomal fragile sites and cancer.

6. Human chromosome hot points. 1. Hot point at 3p14 in three populations.

7. Fragile sites and structural rearrangements in cancer.

8. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

9. The most common fragile site in man is 3p14.