Literature DB >> 6849788

The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug.

S George, K Dauwe, A McBurney, J Ward.   

Abstract

The effects of food ingestion on the absorption of timegadine, a recently synthesised non-steroidal anti-inflammatory drug, was studied in ten healthy volunteers. It was found that food enhanced the absorption of timegadine as shown by increased peak plasma concentrations (Cmax), decreased time taken to achieve these concentrations (tmax), and increased area under the plasma concentration time curve (AUC).

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Year:  1983        PMID： 6849788      PMCID： PMC1427812          DOI： 10.1111/j.1365-2125.1983.tb01537.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  12 in total

1.  How food and fluid affect drug absorption: results of initial studies.

Authors:  P G Welling
Journal:  Postgrad Med       Date:  1977-07       Impact factor: 3.840

2.  Enhancement of the bioavailability of propranolol and metoprolol by food.

Authors:  A Melander; K Danielson; B Scherstén; E Wåhlin
Journal:  Clin Pharmacol Ther       Date:  1977-07       Impact factor: 6.875

Review 3.  Drug kinetics and hepatic blood flow.

Authors:  C F George
Journal:  Clin Pharmacokinet       Date:  1979 Nov-Dec       Impact factor: 6.447

Review 4.  Influence of food on the bioavailability of drugs.

Authors:  A Melander
Journal:  Clin Pharmacokinet       Date:  1978 Sep-Oct       Impact factor: 6.447

5.  A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation.

Authors:  I Ahnfelt-Rønne; E Arrigoni-Martelli
Journal:  Biochem Pharmacol       Date:  1980-12       Impact factor: 5.858

Review 6.  The effect of food on drug bioavailability.

Authors:  R D Toothaker; P G Welling
Journal:  Annu Rev Pharmacol Toxicol       Date:  1980       Impact factor: 13.820

7.  Effect of food on the bioavailability of labetalol.

Authors:  R Mäntylä; H Allonen; J Kanto; T Kleimola; R Sellman
Journal:  Br J Clin Pharmacol       Date:  1980-04       Impact factor: 4.335

8.  Indomethacin serum concentrations in man. Effects of dosage, food, and antacid.

Authors:  H W Emori; H Paulus; R Bluestone; G D Champion; C Pearson
Journal:  Ann Rheum Dis       Date:  1976-08       Impact factor: 19.103

Review 9.  Prostaglandins, arachidonic acid, and inflammation.

Authors:  F A Kuehl; R W Egan
Journal:  Science       Date:  1980-11-28       Impact factor: 47.728

10.  The influence of food on the absorption of diclofenac after single and multiple oral doses.

Authors:  J V Willis; M J Kendall; D B Jack
Journal:  Eur J Clin Pharmacol       Date:  1981-01       Impact factor: 2.953
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  5 in total

1.  Effects of antirheumatic drugs on leukotriene B4 and prostanoid synthesis in human polymorphonuclear leukocytes in vitro.

Authors:  E Moilanen; J Alanko; E Seppälä; H Vapaatalo
Journal:  Agents Actions       Date:  1988-07

Review 2.  Effects of food on clinical pharmacokinetics.

Authors:  B N Singh
Journal:  Clin Pharmacokinet       Date:  1999-09       Impact factor: 6.447

3.  The protein binding of timegadine determined by equilibrium dialysis.

Authors:  S George; A McBurney; J Ward
Journal:  Br J Clin Pharmacol       Date:  1984-11       Impact factor: 4.335

4.  The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen.

Authors:  S George; A McBurney; J W Ward
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

Review 5.  Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs - a systematic review.

Authors:  Robert Andrew Moore; Sheena Derry; Philip J Wiffen; Sebastian Straube
Journal:  Br J Clin Pharmacol       Date:  2015-07-06       Impact factor: 4.335
  5 in total

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