Literature DB >> 6783045

A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation.

I Ahnfelt-Rønne, E Arrigoni-Martelli.   

Abstract

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Year:  1980        PMID: 6783045     DOI: 10.1016/0006-2952(80)90301-9

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN: 0006-2952            Impact factor:   5.858


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  11 in total

Review 1.  12-lipoxygenase: a potential target for novel anti-platelet therapeutics.

Authors:  Jennifer Yeung; Michael Holinstat
Journal:  Cardiovasc Hematol Agents Med Chem       Date:  2011-07-01

2.  An unusual profile of activity of a new basic anti-inflammatory drug, timegadine.

Authors:  E Bramm; L Binderup; E Arrigoni-Martelli
Journal:  Agents Actions       Date:  1981-07

3.  The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug.

Authors:  S George; K Dauwe; A McBurney; J Ward
Journal:  Br J Clin Pharmacol       Date:  1983-04       Impact factor: 4.335

4.  Comparison timegadine versus naproxen in rheumatoid arthritis.

Authors:  M O'Sullivan; M G Molloy
Journal:  Clin Rheumatol       Date:  1985-09       Impact factor: 2.980

5.  Comparison of timegadine and naproxen in rheumatoid arthritis. A placebo controlled trial.

Authors:  H Berry; B Bloom; L Fernandes; M Morris
Journal:  Clin Rheumatol       Date:  1983-12       Impact factor: 2.980

6.  Histamine, 5-hydroxytryptamine and compound 48/80 activate PMN-leucocyte collagenase of the rat.

Authors:  E Wojtecka-Lukasik; S Maśliński
Journal:  Agents Actions       Date:  1984-04

7.  Timegadine: long-term open study in rheumatoid arthritis.

Authors:  I Caruso; M Fumagalli; F Montrone; M Greco; L Boccassini
Journal:  Clin Rheumatol       Date:  1983-12       Impact factor: 2.980

8.  Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.

Authors:  E Seppälä; M Nissilä; H Isomäki; P Nuotio; E Nykänen; O Laitinen; H Vapaatalo
Journal:  Clin Rheumatol       Date:  1985-09       Impact factor: 2.980

9.  The protein binding of timegadine determined by equilibrium dialysis.

Authors:  S George; A McBurney; J Ward
Journal:  Br J Clin Pharmacol       Date:  1984-11       Impact factor: 4.335

10.  Chronic inflammation in adjuvant arthritic rats correlates with enhancement of 12-L-HETE-synthesis.

Authors:  I Ahnfelt-Rønne; E Bramm; E Arrigoni-Martelli
Journal:  Agents Actions       Date:  1981-12
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