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Literature DB >> 6832286

Human lactotransferrin: molecular, functional and evolutionary comparisons with human serum transferrin and hen ovotransferrin.

J Mazurier, M H Metz-Boutigue, J Jollès, G Spik, J Montreuil, P Jollès.

Abstract

In this review article, human lactotransferrin is compared to human serum transferrin and hen ovotransferrin. For the first time the possibility of a 6-fold internal homology of the transferrins is raised: a scheme in which 6 domains are defined is reported; two of them with the highest homology seem to be implicated in the 2 iron binding sites of each transferrin. The location of the disulfide bridges of the 3 transferrins and of their prosthetic sugar groups is discussed: some not yet described half-cystine containing lactotransferrin peptides are indicated.

Entities: Chemical Gene Species

Mesh：

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Year: 1983 PMID： 6832286 DOI： 10.1007/bf01958861

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

25 in total

2. Comparison of human lactoferrins from milk and neutrophilic leucocytes. Relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver.

Authors: N Moguilevsky; L A Retegui; P L Masson
Journal: Biochem J Date: 1985-07-15 Impact factor: 3.857

2 in total

Human lactotransferrin: molecular, functional and evolutionary comparisons with human serum transferrin and hen ovotransferrin.

1. Carbohydrate-peptide linkage in glycoproteins.

2. Evidence for an internal homology in human lactoferrin structure [proceedings].

3. The primary structure of hen ovotransferrin.

4. The identification of protected tyrosine residues in iron-ovotransferrin.

5. Structural relatedness between human lactotransferrin and human ceruloplasmin.

6. Enzymatic N-glycosylation of synthetic Asn--X--Thr containing peptides.

7. The complete amino acid sequence of human serum transferrin.

8. The synergistic binding of anions and Fe3+ by transferrin. Implications for the interlocking sites hypothesis.

9. The formation of iron-binding fragments of hen ovotransferrin by limited proteolysis.

10. Location of the carbohydrate groups of ovomucoid.

1. Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

2. Comparison of human lactoferrins from milk and neutrophilic leucocytes. Relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver.