Literature DB >> 6812058

Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization.

S Malcolm, P Barton, C Murphy, M A Ferguson-Smith, D L Bentley, T H Rabbitts.   

Abstract

The genes for human immunoglobulin kappa light chains have been localized in normal lymphocyte and fibroblast chromosomes by in situ hybridization of probes from cloned DNA fragments of the kappa variable region locus. The localization was achieved by counting grains (after autoradiography) over chromosomes in a number of karyotypes. The variable region gene probes hybridized in a cluster on a region of the chromosome 2 short arm close to the centromere (2cen leads to p12). This location was confirmed in lymphocytes from a balanced translocation carrier 46XXt (2; 16) (q13; q22). Our results show that human kappa light chain genes are located in the region of the break point observed in specific chromosomal translocations associated with Burkitt lymphoma.

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Year:  1982        PMID： 6812058      PMCID： PMC346804          DOI： 10.1073/pnas.79.16.4957

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Chromosome preparations of leukocytes cultured from human peripheral blood.

Authors:  P S MOORHEAD; P C NOWELL; W J MELLMAN; D M BATTIPS; D A HUNGERFORD
Journal:  Exp Cell Res       Date:  1960-09       Impact factor: 3.905

Review 2.  Report of the committee on the genetic constitution of chromosomes 7, 8, and 9.

Authors:  P Meera Khan; E B Robson
Journal:  Cytogenet Cell Genet       Date:  1979

3.  [Chromosomal studies from cell cultures. Technical modifications].

Authors:  J de Grouchy; C Billardon; M Roubin
Journal:  Ann Genet       Date:  1970-06

4.  Chromosomal localization of a single copy gene by in situ hybridization--human beta globin genes on the short arm of chromosome 11.

Authors:  S Malcolm; P Barton; C Murphy; M A Ferguson-Smith
Journal:  Ann Hum Genet       Date:  1981-05       Impact factor: 1.670

5.  Localization of the human alpha-globin gene cluster to the short arm of chromosome 16 (16p12-16pter) by hybridization in situ.

Authors:  P Barton; S Malcolm; C Murphy; M A Ferguson-Smith
Journal:  J Mol Biol       Date:  1982-04-05       Impact factor: 5.469

6.  Assignment of the genes for human lambda immunoglobulin chains to chromosome 22.

Authors:  J Erikson; J Martinis; C M Croce
Journal:  Nature       Date:  1981-11-12       Impact factor: 49.962

7.  The role of gene dosage and genetic transpositions in carcinogenesis.

Authors:  G Klein
Journal:  Nature       Date:  1981-11-26       Impact factor: 49.962

8.  Chromosomal location of the genes for human immunoglobulin heavy chains.

Authors:  C M Croce; M Shander; J Martinis; L Cicurel; G G D'Ancona; T W Dolby; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

9.  The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors:  R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

10.  Immunoglobulin heavy chain genes in humans are located on chromosome.

Authors:  M J Hobart; T H Rabbitts; P N Goodfellow; E Solomon; S Chambers; N Spurr; S Povey
Journal:  Ann Hum Genet       Date:  1981-10       Impact factor: 1.670
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  56 in total

1.  The mink gene for the lambda light immunoglobulin chain: characterization of cDNA and chromosomal localization.

Authors:  T M Khlebodarova; N M Matveeva; O L Serov; A M Najakshin; E S Belousov; S V Bogachev; O K Baranov
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  A human immunoglobulin kappa orphon without sequence defects may be the product of a pericentric inversion.

Authors:  C Huber; R Thiebe; H Hameister; H Smola; E Lötscher; H G Zachau
Journal:  Nucleic Acids Res       Date:  1990-06-25       Impact factor: 16.971

3.  The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.

Authors:  M von Lindern; A Poustka; H Lerach; G Grosveld
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

4.  Assignment of pig immunoglobulin kappa gene IGKC, to chromosome 3q12-q14 by fluorescence in situ hybridization (FISH).

Authors:  G Rettenberger; J Bruch; T Leeb; B Brenig; C Klett; H Hameister
Journal:  Mamm Genome       Date:  1996-04       Impact factor: 2.957

5.  Characterization of a germline Vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus.

Authors:  N Suzuki; T Harada; S Mihara; T Sakane
Journal:  J Clin Invest       Date:  1996-10-15       Impact factor: 14.808

6.  Probable involvement of immunoglobulin superfamily genes in most recurrent chromosomal rearrangements from ataxia telangiectasia.

Authors:  A Aurias; B Dutrillaux
Journal:  Hum Genet       Date:  1986-03       Impact factor: 4.132

7.  Localization of the thyroglobulin gene by in situ hybridization to human chromosomes.

Authors:  J L Bergé-Lefranc; G Cartouzou; M G Mattéi; E Passage; C Malezet-Desmoulins; S Lissitzky
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

Review 8.  Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

Authors:  L Larizza; V Schirrmacher
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

9.  The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) translocation involves the immunoglobulin heavy chain locus.

Authors:  J Erikson; J Finan; Y Tsujimoto; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

Review 10.  DNA rearrangements in human B- and T-cell malignancies.

Authors:  C I Smith; L Hammarström
Journal:  Med Oncol Tumor Pharmacother       Date:  1986
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