Literature DB >> 6808518

The 48-base-long primordial building block of immunoglobulin light-chain variable regions is complementary to the primordial building block of heavy-chain variable regions.

S Ohno, T Matsunaga.   

Abstract

The ancestral gene for immunoglobulin light-chain variable regions (Ig VLs) of the kappa as well as the lambda class apparently arose from about 12 tandem repeats of the 48-base-long primordial building block sequence TCT-TGC-GCA-GTA-AGT-CCA-CTC-CAG-GTC-ATA-TCC-AGT-CAG-GCT-GCT-GAA. Even today, amino acid residues 67 to 82 of each Ig V kappa L are still specified by a direct descendant in toto of the above-noted primordial building block, whereas amino acid residues 14 to 25 are invariably specified by its truncated copy. The Ig VL primordial building block presently identified is 100% complementary to the Ig VH (heavy-chain variable region) primordial building block previously identified. In the recognition of specific antigenic determinants by antibodies, Ig VL and Ig VH of light-chain--heavy-chain dimers have to complement each other. It is perhaps fitting that the primordial building blocks of the two are represented by the complementary strands of the same 48-base-pair-long DNA sequence.

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Year:  1982        PMID： 6808518      PMCID： PMC346188          DOI： 10.1073/pnas.79.7.2338

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

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Authors:  J G Seidman; E E Max; P Leder
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Review 2.  The protein products of the murine 17th chromosome: genetics and structure.

Authors:  E S Vitetta; J D Capra
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3.  Histocompatibility-2 system in wild mice. V. Serologic analysis of sixteen B10.W congenic lines.

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Journal:  J Immunol       Date:  1977-12       Impact factor: 5.422

4.  Cytotoxic reactions of anti-H-2 sera with human lymphocytes.

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5.  Cross-reactions of cattle lymphocytotoxic sera with HL-A and other human antigens.

Authors:  T H Iha; G Gerbrandt; W F Bodmer; D McGary; W H Stone
Journal:  Tissue Antigens       Date:  1973

6.  Detection of human lymphocyte isoantigens by rabbit homotransplantation sera.

Authors:  E Albert; K Kano; C J Abeyounis; F Milgrom
Journal:  Transplantation       Date:  1969-10       Impact factor: 4.939

Review 7.  Preliminary amino acid sequences of transplantation antigens: genetic and evolutionary implications.

Authors:  J Silver; L Hood
Journal:  Contemp Top Mol Immunol       Date:  1976

8.  Primary structure of murine major histocompatibility complex alloantigens: amino acid sequence of the amino-terminal one hundred and seventy-three residues of the H-2Kb glycoprotein.

Authors:  H Uehara; B M Ewenstein; J M Martinko; S G Nathenson; J E Coligan; T J Kindt
Journal:  Biochemistry       Date:  1980-01-22       Impact factor: 3.162

9.  New genetic model for allelism at histocompatibility and other complex loci: polymorphism for control of gene expression.

Authors:  W F Bodmer
Journal:  Transplant Proc       Date:  1973-12       Impact factor: 1.066

10.  [The inbred mouse strain STU. Development and properties (author's transl)].

Authors:  W Schäfer
Journal:  Z Naturforsch C Biosci       Date:  1979 Mar-Apr
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  7 in total

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2.  Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains.

Authors:  P P Chen; E A Kabat; T T Wu; S Fong; D A Carson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

3.  The genome of the THE I human transposable repetitive elements is composed of a basic motif homologous to an ancestral immunoglobulin gene sequence.

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4.  Recurrence of 49-base decamers, nonomers, and octamers within mouse C mu gene of Ig heavy chain and its primordial building block.

Authors:  A Yazaki; S Ohno
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

5.  Balbiani ring DNA: sequence comparisons and evolutionary history of a family of hierarchically repetitive protein-coding genes.

Authors:  J Pustell; F C Kafatos; U Wobus; H Bäumlein
Journal:  J Mol Evol       Date:  1984       Impact factor: 2.395

6.  Identification of the 45-base-long primordial building block of the entire class I major histocompatibility complex antigen gene.

Authors:  S Ohno; T Matsunaga; J T Epplen; K Itakura; R B Wallace
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

7.  "A Japanese gentleman of the Samurai tradition": Takeshi Matsunaga 1945-2003.

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  7 in total

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