Literature DB >> 8058743

The genome of the THE I human transposable repetitive elements is composed of a basic motif homologous to an ancestral immunoglobulin gene sequence.

I Hakim1, N Amariglio, Z Grossman, F Simoni-Brok, S Ohno, G Rechavi.   

Abstract

Amplification of rearranged human immunoglobulin heavy-chain genes using the polymerase chain reaction resulted unexpectedly in the amplification of human transposable repetitive element genomes. These were identified as members of the THE I (transposon-like human element I) transposable element family. Analysis of the THE I sequences revealed the presence of several copies of the ancestral building block described > 10 years ago by Ohno and coworkers as the primordial immunoglobulin sequence. The frequency and degree of homology of the repeats of the basic unit were similar for the two genes, as well as for two murine intracisternal A particles. These findings suggest that both the transposable genetic elements and the immunoglobulin genes originated from a common ancestral building block.

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Year:  1994        PMID： 8058743      PMCID： PMC44525          DOI： 10.1073/pnas.91.17.7967

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes.

Authors:  J V Ravetch; U Siebenlist; S Korsmeyer; T Waldmann; P Leder
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

2.  The genetics of antibody diversity.

Authors:  P Leder
Journal:  Sci Am       Date:  1982-05       Impact factor: 2.142

3.  Recurrence of 49-base decamers, nonomers, and octamers within mouse C mu gene of Ig heavy chain and its primordial building block.

Authors:  A Yazaki; S Ohno
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

4.  SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes.

Authors:  M F Singer
Journal:  Cell       Date:  1982-03       Impact factor: 41.582

Review 5.  Somatic generation of antibody diversity.

Authors:  S Tonegawa
Journal:  Nature       Date:  1983-04-14       Impact factor: 49.962

6.  The 48-base-long primordial building block of immunoglobulin light-chain variable regions is complementary to the primordial building block of heavy-chain variable regions.

Authors:  S Ohno; T Matsunaga
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

7.  Mouse immunoglobulin coding sequences for the heavy-chain variable region arose as repeats of the two short building blocks.

Authors:  S Ohno; K Kato; T Hozumi; T Matsunaga
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

Review 8.  Insertional mutagenesis by transposable elements in the mammalian genome.

Authors:  N Amariglio; G Rechavi
Journal:  Environ Mol Mutagen       Date:  1993       Impact factor: 3.216

9.  Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.

Authors:  S Ohno; T Matsunaga; R B Wallace
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

10.  Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes.

Authors:  J V Ravetch; I R Kirsch; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205
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  1 in total

Review 1.  Reverse transcriptase: mediator of genomic plasticity.

Authors:  J Brosius; H Tiedge
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332
  1 in total

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