Literature DB >> 3920660

Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains.

P P Chen, E A Kabat, T T Wu, S Fong, D A Carson.   

Abstract

The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region kappa chain (V kappa) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one V kappa sequence, the homology includes the 5' flanking region of D minigenes, which may comprise a recombinase recognition signal. It is thus conceivable that gene conversions involving D minigenes may contribute to V kappa diversity.

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Year:  1985        PMID： 3920660      PMCID： PMC397505          DOI： 10.1073/pnas.82.7.2125

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  45 in total

1.  Composite human VK genes and a model of their evolution.

Authors:  H R Jaenichen; M Pech; W Lindenmaier; N Wildgruber; H G Zachau
Journal:  Nucleic Acids Res       Date:  1984-07-11       Impact factor: 16.971

2.  Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region.

Authors:  N Takahashi; T Noma; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

3.  Localization of a T-cell receptor diversity-region element.

Authors:  J Kavaler; M M Davis; Y Chien
Journal:  Nature       Date:  1984 Aug 2-8       Impact factor: 49.962

4.  The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene.

Authors:  G Siu; S P Clark; Y Yoshikai; M Malissen; Y Yanagi; E Strauss; T W Mak; L Hood
Journal:  Cell       Date:  1984-06       Impact factor: 41.582

5.  Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes.

Authors:  N R Gascoigne; Y Chien; D M Becker; J Kavaler; M M Davis
Journal:  Nature       Date:  1984 Aug 2-8       Impact factor: 49.962

6.  Correct transcription of an immunoglobulin kappa gene requires an upstream fragment containing conserved sequence elements.

Authors:  F G Falkner; H G Zachau
Journal:  Nature       Date:  1984 Jul 5-11       Impact factor: 49.962

7.  Somatic recombination in a murine T-cell receptor gene.

Authors:  Y H Chien; N R Gascoigne; J Kavaler; N E Lee; M M Davis
Journal:  Nature       Date:  1984 May 24-30       Impact factor: 49.962

8.  Molecular basis of a mouse strain-specific anti-hapten response.

Authors:  D Y Loh; A L Bothwell; M E White-Scharf; T Imanishi-Kari; D Baltimore
Journal:  Cell       Date:  1983-05       Impact factor: 41.582

9.  Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide.

Authors:  M Malissen; K Minard; S Mjolsness; M Kronenberg; J Goverman; T Hunkapiller; M B Prystowsky; Y Yoshikai; F Fitch; T W Mak
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

10.  Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.

Authors:  R Dildrop; M Brüggemann; A Radbruch; K Rajewsky; K Beyreuther
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
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  2 in total

1.  Structural features of transposed human VK genes and implications for the mechanism of their transpositions.

Authors:  P Borden; R Jaenichen; H G Zachau
Journal:  Nucleic Acids Res       Date:  1990-04-25       Impact factor: 16.971

2.  Chicken immunoglobulin gamma-heavy chains: limited VH gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus.

Authors:  R Parvari; A Avivi; F Lentner; E Ziv; S Tel-Or; Y Burstein; I Schechter
Journal:  EMBO J       Date:  1988-03       Impact factor: 11.598
  2 in total

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