Literature DB >> 6790851

Use of alpha-methylphenylalanine for studies of brain development in experimental phenylketonuria.

G Huether, V Neuhoff.   

Abstract

Experimental phenylketonuria was induced in newborn rats by administration of L-phenylalanine and alpha-methylphenylalanine. There was no primary disturbance of myelination, but reduced cell proliferation, early cell death and compensatory hyperplasia were evident in the cerebellum.

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Year:  1981        PMID： 6790851     DOI： 10.1007/BF02263594

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  10 in total

1.  [On the pathogenesis of feeble-mindedness in phenylketonuria].

Authors:  F LINNEWEH; M EHRLICH
Journal:  Klin Wochenschr       Date:  1962-03-01

2.  Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats.

Authors:  O Greengard; M S Yoss; J A Del Valle
Journal:  Science       Date:  1976-06-04       Impact factor: 47.728

3.  Abnormal amino acid metabolism and brain protein synthesis during neural development.

Authors:  J V Hughes; T C Johnson
Journal:  Neurochem Res       Date:  1978-08       Impact factor: 3.996

4.  Myelination in rat brain: method of myelin isolation.

Authors:  W T Norton; S E Poduslo
Journal:  J Neurochem       Date:  1973-10       Impact factor: 5.372

5.  Brain development in experimental hyperphenylalaninaemia: disturbed proliferation and reduced cell numbers in the cerebellum.

Authors:  G Huether; V Neuhoff; R Kaus
Journal:  Neuropediatrics       Date:  1983-02       Impact factor: 1.947

6.  Experimental hyperphenylalaninemia: effect on central nervous system myelin subfractions.

Authors:  D A Figlewicz; M J Druse
Journal:  Exp Neurol       Date:  1980-02       Impact factor: 5.330

7.  Brain protein and myelin metabolism in hyperphenylalaninemic rats.

Authors:  R Berger; J Springer; F A Hommes
Journal:  Cell Mol Biol Incl Cyto Enzymol       Date:  1980

8.  p-Chlorophenylalanine-induced chemical manifestations of phenylketonuria in rats.

Authors:  M A Lipton; R Gordon; G Guroff; S Udenfriend
Journal:  Science       Date:  1967-04-14       Impact factor: 47.728

9.  Characterization of experimental phenylketonuria. Augmentation of hyperphenylalaninemia with alpha-methylphenylalanine and p-chlorophenylalanine.

Authors:  J D Lane; B Schöne; U Langenbeck; V Neuhoff
Journal:  Biochim Biophys Acta       Date:  1980-01-17

10.  Phenylketonuria: clinical and experimental considerations revealed by the use of animal models.

Authors:  J D Lane; V Neuhoff
Journal:  Naturwissenschaften       Date:  1980-05
  10 in total
  1 in total

1.  Mouse models of human phenylketonuria.

Authors:  A Shedlovsky; J D McDonald; D Symula; W F Dove
Journal:  Genetics       Date:  1993-08       Impact factor: 4.562
  1 in total

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