Literature DB >> 6067026

p-Chlorophenylalanine-induced chemical manifestations of phenylketonuria in rats.

M A Lipton, R Gordon, G Guroff, S Udenfriend.   

Abstract

p-Chlorophenylalanine, a potent inhibitor of phenylalanine hydroxylase in vivo, has been used to simulate phenylketonuria in rats. This inhibitor, when administered with phenylalanine, produces marked elevation of blood and tissue phenylalanine without an increase in tyrosine. Disproportionate ratios of phenylalanine to tyrosine are characteristic of phenylketonuria in humans. The use of p-chlorophenylalanine permits the production of this characteristics amino acid imbalance in experimental animals.

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Year:  1967        PMID： 6067026     DOI： 10.1126/science.156.3772.248

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Effect of phenylalanine and p-chlorophenylalanine on Na+, K+-ATPase activity in the synaptic plasma membrane from the cerebral cortex of rats.

Authors:  E L Streck; P T Edom; M E Noriler; L F Borges; Z L Pontes; E Parolo; C S Dutra-Filho; C M Wannmacher; A T Wyse
Journal:  Metab Brain Dis       Date:  2000-06       Impact factor: 3.584

2.  Abnormal amino acid metabolism and brain protein synthesis during neural development.

Authors:  J V Hughes; T C Johnson
Journal:  Neurochem Res       Date:  1978-08       Impact factor: 3.996

3.  Enduring behavioral changes in rats with experimental phenylketonuria.

Authors:  A E Andersen; G Guroff
Journal:  Proc Natl Acad Sci U S A       Date:  1972-04       Impact factor: 11.205

4.  Parachlorophenylalanine treatment in carcinoid syndrome.

Authors:  M Shani; C Sheba
Journal:  Br Med J       Date:  1970-12-26

5.  Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors.

Authors:  Kevin M Cheung; Kyung-Ae Yang; Nako Nakatsuka; Chuanzhen Zhao; Mao Ye; Michael E Jung; Hongyan Yang; Paul S Weiss; Milan N Stojanović; Anne M Andrews
Journal:  ACS Sens       Date:  2019-11-01       Impact factor: 7.711

6.  beta-2-Thienyl-DL-alanine as an inhibitor of phenylalanine hydroxylase and phenylalanine intestinal transport.

Authors:  R A Wapnir; G S Moak
Journal:  Biochem J       Date:  1979-01-01       Impact factor: 3.857

7.  Distribution and metabolism of phenylalanine and tyrosine during tualraemia in the rat.

Authors:  M C Powanda; R E Dinterman; R W Wannemacher; G D Herbrandson
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857

8.  Liver phenylalanine hydroxylase activity in relation to blood concentrations of tyrosine and phenylalanine in the rat.

Authors:  M M McGee; O Greengard; W E Knox
Journal:  Biochem J       Date:  1972-05       Impact factor: 3.857

9.  Demonstration and distribution of phenylethanolamine in brain and other tissues.

Authors:  J M Saavedra; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

10.  The enduring behavioral changes in rats with experimental phenylketonuria.

Authors:  A E Andersen; V Rowe; G Guroff
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205
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