Literature DB >> 6788888

Influence of Igh-linked gene products on the generation of T helper cells in the response to sheep erythrocytes.

N Nutt, J Haber, H H Wortis.   

Abstract

The role of Igh-linked loci in the generation and expression of T cell help for antibody responses to sheep erythrocytes (SRBC) was investigated. The production of IgM, IgG3, IgG1, IgG2b, and IgG2a antibody to SRBC was shown to be T cell dependent. The Igh-congenic mouse pair CBA/Tufts (Ighj) and CBA.Ighb gave equivalent responses to SRBC. CBA.nude mice (Ighj) supplemented with peripheral T cells of either Ighj or Ighb genotype produced equivalent, high responses. Therefore, T cell-B cell mismatching for the Igh haplotype is not in itself a bar to the generation or expression of help. In contrast, T cells primed in an environment that lacks Ighj-linked products are inefficient helpers for Ighj B cells. These results suggest that antigen-primed B cells or their products prime a set of T cells that can help B cells that bear matching, Igh-linked gene products.

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Year:  1981        PMID： 6788888      PMCID： PMC2186170          DOI： 10.1084/jem.153.5.1225

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  24 in total

1.  Immunoglobulin isoantigens (allotypes) in the mouse. 3. Detection of allotypic antigens with heterologous antisera.

Authors:  N L Warner; L A Herzenberg
Journal:  J Immunol       Date:  1966-10       Impact factor: 5.422

2.  Regulation of antibody response in vitro. VI. Carrier-specific helper cells for IgG and IgE antibody response.

Authors:  T Kishimoto; K Ishizaka
Journal:  J Immunol       Date:  1973-09       Impact factor: 5.422

3.  Immunological activity of thymus and thoracic-duct lymphocytes.

Authors:  G F Mitchell; J F Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1968-01       Impact factor: 11.205

4.  Thymus dependence of antibody response: variation with dose of antigen and class of antibody.

Authors:  R B Taylor; H H Wortis
Journal:  Nature       Date:  1968-11-30       Impact factor: 49.962

5.  Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

Authors:  C A Janeway; R A Murgita; F I Weinbaum; R Asofsky; H Wigzell
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

6.  Immune responses in congenitally thymus-less mice. II. Quantitative studies of serum immunoglobulins, the antibody response to sheep erythrocytes, and the effect of thymus allografting.

Authors:  H Pritchard; J Riddaway; H S Micklem
Journal:  Clin Exp Immunol       Date:  1973-01       Impact factor: 4.330

7.  Thymus-marrow cell combinations. Synergism in antibody production.

Authors:  H N Claman; E A Chaperon; R F Triplett
Journal:  Proc Soc Exp Biol Med       Date:  1966 Aug-Sep

8.  Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin.

Authors:  M G Mage; L L McHugh; T L Rothstein
Journal:  J Immunol Methods       Date:  1977       Impact factor: 2.303

9.  Quantitative measurement of mouse IgG subclasses with the use of heteroantisera: the importance of allotype considerations.

Authors:  S L Epstein; P D Gottlieb
Journal:  J Immunol       Date:  1977-03       Impact factor: 5.422

10.  T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.

Authors:  L A Herzenberg; K Okumura; H Cantor; V L Sato; F W Shen; E A Boyse; L A Herzenberg
Journal:  J Exp Med       Date:  1976-08-01       Impact factor: 14.307
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  16 in total

1.  Correlation of the Km(1) immunoglobulin allotype with anti-polysaccharide antibodies in Caucasian adults.

Authors:  D M Ambrosino; V A Barrus; G G DeLange; G R Siber
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

2.  The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse.

Authors:  R C Kuppers; L D Epstein; I M Outschoorn; N R Rose
Journal:  Immunogenetics       Date:  1994       Impact factor: 2.846

3.  Differences in putative minor histocompatibility but not IgH genes can prevent T-cell priming and T--B co-operation in the response of mice to sheep erythrocytes.

Authors:  D W Dresser; A M Popham; R Hunt
Journal:  Immunology       Date:  1982-07       Impact factor: 7.397

4.  The collaborative phenotype of secondary B cells is determined by T lymphocytes during in vivo immunization.

Authors:  N A Speck; S K Pierce
Journal:  J Exp Med       Date:  1982-02-01       Impact factor: 14.307

5.  Homologies between cell interaction molecular controlled by major histocompatibility complex- and Igh-V-linked genes that T cells use for communication. Tandem "adaptive" differentiation of producer and acceptor cells.

Authors:  P Flood; K Yamauchi; A Singer; R K Gershon
Journal:  J Exp Med       Date:  1982-11-01       Impact factor: 14.307

6.  Antiidiotypes against anti-H-2 monoclonal antibodies. V. In vivo antiidiotype treatment induces idiotype-specific helper T cells.

Authors:  H Auchincloss; J A Bluestone; D H Sachs
Journal:  J Exp Med       Date:  1983-04-01       Impact factor: 14.307

7.  Expression of murine Lm-1 locus. Lm-1 determinants on lymphocytes and macrophages, and effects of Lm-1 incompatibility on bone marrow grafts.

Authors:  M M O'Toole; G C Bosma; M J Bosma
Journal:  J Exp Med       Date:  1985-08-01       Impact factor: 14.307

8.  Idiotype-specific T lymphocytes. II. capability of generation of idiotype-specific T lymphocytes is determined by corresponding VH gene.

Authors:  H Yamamoto; S Bitoh; S Fujimoto
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

9.  Lack of mature B cells in nude mice with X-linked immune deficiency.

Authors:  H H Wortis; L Burkly; D Hughes; S Roschelle; G Waneck
Journal:  J Exp Med       Date:  1982-03-01       Impact factor: 14.307

10.  Priming of T helper cells by antigen-activated B cells. B cell-primed Lyt-1+ helper cells are restricted to cooperate with B cells expressing the IgvH phenotype of the priming B cells.

Authors:  J L'Age-Stehr
Journal:  J Exp Med       Date:  1981-05-01       Impact factor: 14.307
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