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Literature DB >> 73181

Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

C A Janeway, R A Murgita, F I Weinbaum, R Asofsky, H Wigzell.

Abstract

Evidence from various systems suggests that thymus-derived lymphocytes can affect the quality of antibody responses by recognizing various portions of the immunoglobulin receptor of bone-marrow-derived thymus-independent lymphocytes. A model for this process is proposed involving two antigen-specific mature T helper cells, one of which also is specific for immunoglobulin determinants. These two cells act synergistically. Evidence from adoptive secondary antibody responses demonstrates that both cells are antigen-specific T cells and that the immunoglobulin-recognizing T helper cell is absent from experimentally agammaglobulinemic mice. This cell is termed an "immunoglobulin-dependent T cell" because its activation requires the presence of immunoglobulin.

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Year: 1977 PMID： 73181 PMCID： PMC431990 DOI： 10.1073/pnas.74.10.4582

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.

Authors: N A Mitchison
Journal: Eur J Immunol Date: 1971-01 Impact factor: 5.532

2. Cellular cooperation during in vivo anti-hapten antibody responses. II. The effect of in vivo and in vitro x-irradiation on T and B cells.

Authors: C A Janeway
Journal: J Immunol Date: 1975-04 Impact factor: 5.422

3. A simple conservative explanation of the H-2 restriction of interactions between lymphocytes.

Authors: A J Cunningham; K J Lafferty
Journal: Scand J Immunol Date: 1977 Impact factor: 3.487

Review 4. Functional specificity of thymus- dependent lymphocytes.

Authors: W E Paul; B Benacerraf
Journal: Science Date: 1977-03-25 Impact factor: 47.728

5. Cellular cooperation during in vivo anti-hapten antibody responses. III. The helper cell activity of activated thymocytes, of spleen cells treated with anti-theta serum, and of spleen cells from anti-thymocyte serum-treated or adult thymectomized donors.

Authors: C A Janeway
Journal: J Immunol Date: 1975-04 Impact factor: 5.422

6. Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.

Authors: C A Janeway
Journal: J Immunol Date: 1975-04 Impact factor: 5.422

7. Immunity to Plasmodium Berghei yoelii in mice. I. The course of infection in T cell and B cell deficient mice.

Authors: F I Weinbaum; C B Evans; R E Tigelaar
Journal: J Immunol Date: 1976-11 Impact factor: 5.422

8. Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.

Authors: K Okumura; L A Herzenberg; D B Murphy; H O McDevitt; L A Herzenberg
Journal: J Exp Med Date: 1976-09-01 Impact factor: 14.307

9. Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.

Authors: D H Katz; M Graves; M E Dorf; H Dimuzio; B Benacerraf
Journal: J Exp Med Date: 1975-01-01 Impact factor: 14.307

10. T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.

Authors: L A Herzenberg; K Okumura; H Cantor; V L Sato; F W Shen; E A Boyse; L A Herzenberg
Journal: J Exp Med Date: 1976-08-01 Impact factor: 14.307

41 in total

1. The role of antibodies in the regulation of delayed-type hypersensitivity.

Authors: Y Morikawa; K Kuribayashi; F Yoshikawa; K Fujita; A Mizushima; K Kakudo
Journal: Immunology Date: 1991-09 Impact factor: 7.397

2. Effect of idiotype-specific suppressor T cells on primary and secondary responses.

Authors: F L Owen; A Nisonoff
Journal: J Exp Med Date: 1978-07-01 Impact factor: 14.307

Review 3. Autoregulation of immune responses via idiotype network interactions.

Authors: L S Rodkey
Journal: Microbiol Rev Date: 1980-12

Review 4. Function and regulation of SRBC-induced contrasuppressor T cells which modulate suppression of MOPC-315 cell secretory differentiation in vivo and in vitro.

Authors: J W Rohrer; J D Kemp
Journal: Immunol Res Date: 1988 Impact factor: 2.829

5. T-cell dependent response to immune complexes abrogates B-cell unresponsiveness to pneumococcal cell wall polysaccharide.

Authors: M J Caulfield; D Stanko
Journal: Immunology Date: 1995-11 Impact factor: 7.397

Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

1. The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.

2. Cellular cooperation during in vivo anti-hapten antibody responses. II. The effect of in vivo and in vitro x-irradiation on T and B cells.

3. A simple conservative explanation of the H-2 restriction of interactions between lymphocytes.

Review 4. Functional specificity of thymus- dependent lymphocytes.

5. Cellular cooperation during in vivo anti-hapten antibody responses. III. The helper cell activity of activated thymocytes, of spleen cells treated with anti-theta serum, and of spleen cells from anti-thymocyte serum-treated or adult thymectomized donors.

6. Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.

7. Immunity to Plasmodium Berghei yoelii in mice. I. The course of infection in T cell and B cell deficient mice.

8. Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.

9. Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.

10. T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.

1. The role of antibodies in the regulation of delayed-type hypersensitivity.

2. Effect of idiotype-specific suppressor T cells on primary and secondary responses.

Review 3. Autoregulation of immune responses via idiotype network interactions.

Review 4. Function and regulation of SRBC-induced contrasuppressor T cells which modulate suppression of MOPC-315 cell secretory differentiation in vivo and in vitro.

5. T-cell dependent response to immune complexes abrogates B-cell unresponsiveness to pneumococcal cell wall polysaccharide.

6. Internal complementarities in the immune system: regulation of the expression of helper T-cell idiotypes.

7. Antisuppression: a novel pathway in T cell regulation of B cell function.

8. Avidities of hapten-specific antibodies when the responses are modulated by anti-carrier antibodies.

9. IgM antibodies induce the production of antibodies of the same specificity.

10. Functional deletion of different Ly-1 T-cell-inducer subset activities by Ly-2 suppressor T lymphocytes.