Literature DB >> 8188317

The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse.

R C Kuppers1, L D Epstein, I M Outschoorn, N R Rose.   

Abstract

The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not of the Ighj (CBA) allotype.

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Year:  1994        PMID： 8188317     DOI： 10.1007/bf00176157

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  28 in total

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Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

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Journal:  Eur J Immunol       Date:  1980-02       Impact factor: 5.532

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Journal:  J Immunol       Date:  1988-02-15       Impact factor: 5.422

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  2 in total

1.  Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.

Authors:  Yoshiyuki Ban; David A Greenberg; Erlinda Concepcion; Lucy Skrabanek; Ronald Villanueva; Yaron Tomer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

2.  Differential antigen burden modulates the gamma interferon but not the immunoglobulin response in mice that vary in susceptibility to Sendai virus pneumonia.

Authors:  X Y Mo; M Sangster; S Sarawar; C Coleclough; P C Doherty
Journal:  J Virol       Date:  1995-09       Impact factor: 5.103
  2 in total

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