Literature DB >> 7340445

Chronic inflammation in adjuvant arthritic rats correlates with enhancement of 12-L-HETE-synthesis.

I Ahnfelt-Rønne, E Bramm, E Arrigoni-Martelli.   

Abstract

The development of chronic inflammation in adjuvant arthritic rats was found to be strongly correlated with the appearance in serum of a factor (HSF) which enhanced the formation of 12-L-HETE by platelet-lipoxygenase, and with the serum-concentration of 12-L-HETE. The latter was determined by scanning at 235 nm after extraction and high performance thin-layer chromatography. Arthritic rat platelet-rich plasma (PRP) converted exogenous arachidonic acid to 12-L-HETE at a rate 2.6-fold higher than control rat PRP. By resuspending arthritic rat platelets in normal rat plasma, and normal rat platelets in arthritic rat plasma, this increase in conversion rate was found to be caused by HSF present in the arthritic rat plasma. Treatment of arthritis with non-steroidal anti-inflammatory drugs inhibited HSF activity as well as the increase in serum-12-L-HETE concentration, which indicates a prostaglandin-mediated mechanism of HSF synthesis or release.

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Year:  1981        PMID： 7340445     DOI： 10.1007/bf01978753

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets.

Authors:  S R Turner; J A Tainer; W S Lynn
Journal:  Nature       Date:  1975-10-23       Impact factor: 49.962

2.  A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation.

Authors:  I Ahnfelt-Rønne; E Arrigoni-Martelli
Journal:  Biochem Pharmacol       Date:  1980-12       Impact factor: 5.858

3.  Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes.

Authors:  A W Ford-Hutchinson; M A Bray; M V Doig; M E Shipley; M J Smith
Journal:  Nature       Date:  1980-07-17       Impact factor: 49.962

4.  Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

Authors:  L B Klickstein; C Shapleigh; E J Goetzl
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

5.  Adjuvant arthritic rat serum enhances HETE1 biosynthesis.

Authors:  I Ahnfelt-Rønne; E Arrigoni-Martelli
Journal:  Agents Actions       Date:  1980-12

6.  Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines.

Authors:  S Rachlin; E Bramm; I Ahnfelt-Rønne; E Arrigoni-Martelli
Journal:  J Med Chem       Date:  1980-01       Impact factor: 7.446
  6 in total
  4 in total

1.  Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors.

Authors:  M P Holsapple; G K Yim
Journal:  Inflammation       Date:  1984-09       Impact factor: 4.092

2.  Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4.

Authors:  H Gutheil; O H Nielsen; T M Hansen; B S Thomsen; I Ahnfelt-Rønne
Journal:  Inflamm Res       Date:  1996-01       Impact factor: 4.575

3.  Production of superoxide anion, prostaglandins, and hydroxyeicosatetraenoic acids by macrophages from hypersensitivity-type (Schistosoma mansoni egg) and foreign body-type granulomas.

Authors:  S W Chensue; S L Kunkel; G I Higashi; P A Ward; D L Boros
Journal:  Infect Immun       Date:  1983-12       Impact factor: 3.441

4.  Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma.

Authors:  Min He; Eduard van Wijk; Ruud Berger; Mei Wang; Katrin Strassburg; Johannes C Schoeman; Rob J Vreeken; Herman van Wietmarschen; Amy C Harms; Masaki Kobayashi; Thomas Hankemeier; Jan van der Greef
Journal:  Mediators Inflamm       Date:  2015-10-29       Impact factor: 4.711
  4 in total

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