Literature DB >> 678295

Genetic and biochemical analysis of cycloheximide resistance in the fungus Podospora anserina.

M Crouzet, M Perrot, M Nogueira, J Bégueret.   

Abstract

Genetic analysis of cycloheximide-resistant mutants has shown that at least three genes control the resistance to cycloheximide in Podospora anserina and that the antibiotic resistance is recessive to sensitivity. In vitro and in vivo studies of protein synthesis indicated that for two mutants cycloheximide resistance is associated with the ribosomes. For one of these mutants, the elongation step in protein biosynthesis is insensitive to cycloheximide over a wide range of concentration. In this mutant the resistance to cycloheximide is a property of the 60S subunit.

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Year:  1978        PMID： 678295     DOI： 10.1007/BF00484084

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  16 in total

1.  THE GENETIC BASIS OF ACTIDIONE RESISTANCE IN NEUROSPORA.

Authors:  K S HSU
Journal:  J Gen Microbiol       Date:  1963-09

2.  GENETIC ANALYSIS OF ACTIDIONE RESISTANCE IN SACCHAROMYCES CEREVISIAE.

Authors:  D WILKIE; B K LEE
Journal:  Genet Res       Date:  1965-02       Impact factor: 1.588

3.  Genetics and biochemistry of cycloheximide resistance in Physarum polycephalum.

Authors:  F B Haugli; W F Dove; A Jimenez
Journal:  Mol Gen Genet       Date:  1972

4.  [Selection of actidion-resistant mutants in Neurospora crassa and their genetical and biochemical analysis].

Authors:  A Neuhäuser; W Klingmüller; F Kaudewitz
Journal:  Mol Gen Genet       Date:  1970

5.  The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes.

Authors:  T G Obrig; W J Culp; W L McKeehan; B Hardesty
Journal:  J Biol Chem       Date:  1971-01-10       Impact factor: 5.157

6.  Cycloheximide, an inhibitor of peptide chain termination or release in liver in vivo and in vitro.

Authors:  S Rajalakshmi; H Liang; D S Sarma; R Kisilevsky; E Farber
Journal:  Biochem Biophys Res Commun       Date:  1971-01-22       Impact factor: 3.575

7.  The effects of cycloheximide on energy transfer in rat and guinea pig liver mitochondria.

Authors:  A J Garber; M Jomain-Baum; L Salganicoff; E Farber; R W Hanson
Journal:  J Biol Chem       Date:  1973-03-10       Impact factor: 5.157

Review 8.  Inhibitors of ribosome functions.

Authors:  S Pestka
Journal:  Annu Rev Microbiol       Date:  1971       Impact factor: 15.500

9.  Ribosomal proteins in the fungus Podospora anserina: evidence for an electrophoretically altered 60S protein in a cycloheximide resistant mutant.

Authors:  J Begueret; M Perrot; M Crouzet
Journal:  Mol Gen Genet       Date:  1977-11-14

10.  Cycloheximide resistance in yeast: a property of the 60s ribosomal subunit.

Authors:  S S Rao; A P Grollman
Journal:  Biochem Biophys Res Commun       Date:  1967-12-15       Impact factor: 3.575
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  13 in total

1.  Change in cytoplasmic ribosome properties during gametogenesis in the alga Chlamydomonas reinhardtii.

Authors:  M Picard-Bennoun; P Bennoun
Journal:  Curr Genet       Date:  1985-03       Impact factor: 3.886

2.  Ribosomal control of translational fidelity in Podospora anserina: A suppressor and an antisuppressor affecting the paromomycin-induced misreading in vitro.

Authors:  E Coppin-Raynal
Journal:  Curr Genet       Date:  1982-05       Impact factor: 3.886

3.  The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog.

Authors:  V Coustou; C Deleu; S Saupe; J Begueret
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

4.  The cytoplasmic ribosomes of Chlamydomonas reinhardtii: characterization of antibiotic sensitivity and cycloheximide-resistant mutants.

Authors:  G H Fleming; J E Boynton; N W Gillham
Journal:  Mol Gen Genet       Date:  1987-12

5.  Identification of the structural gene for the S9 ribosomal protein in the fungus Podospora anserina: a new protein involved in the control of translational accuracy.

Authors:  M Dequard-Chablat
Journal:  Mol Gen Genet       Date:  1985

Review 6.  A survey of yeast genomic assays for drug and target discovery.

Authors:  Andrew M Smith; Ron Ammar; Corey Nislow; Guri Giaever
Journal:  Pharmacol Ther       Date:  2010-05-28       Impact factor: 12.310

7.  Analysis of revertants of a ribosomal mutation in Podospora anserina: evidence for new ribosomal mutations which confer hypersensitivity to paromomycin.

Authors:  N Randsholt; F Ibarrondo; M Dequard; M Picard-Bennoun
Journal:  Biochem Genet       Date:  1982-06       Impact factor: 1.890

8.  Mutations affecting translational fidelity in the eucaryote Podospora anserina: characterization of two ribosomal restrictive mutations.

Authors:  M Picard-Bennoun
Journal:  Mol Gen Genet       Date:  1981

9.  A new mutant form of the ribosomal protein L21 in the fungus Podospora anserina: identification of the structural gene for this protein.

Authors:  M Crouzet; J Begueret
Journal:  Mol Gen Genet       Date:  1980

10.  Cold-sensitivity of a double mutant strain combining two ribosomal mutations in the ascomycete Podospora anserina.

Authors:  M Crouzet; J Bégueret
Journal:  Mol Gen Genet       Date:  1978-10-24
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