Literature DB >> 20546776

A survey of yeast genomic assays for drug and target discovery.

Andrew M Smith1, Ron Ammar, Corey Nislow, Guri Giaever.   

Abstract

Over the past decade, the development and application of chemical genomic assays using the model organism Saccharomyces cerevisiae has provided powerful methods to identify the mechanism of action of known drugs and novel small molecules in vivo. These assays identify drug target candidates, genes involved in buffering drug target pathways and also help to define the general cellular response to small molecules. In this review, we examine current yeast chemical genomic assays and summarize the potential applications of each approach. (c) 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20546776      PMCID： PMC2923554          DOI： 10.1016/j.pharmthera.2010.04.012

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  115 in total

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Authors:  Eugene C Butcher; Ellen L Berg; Eric J Kunkel
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5.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Authors:  J Heitman; N R Movva; M N Hall
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

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7.  A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.

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Journal:  Nat Biotechnol       Date:  2009-04-06       Impact factor: 54.908

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Journal:  Science       Date:  2007-06-22       Impact factor: 47.728

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Journal:  Brief Funct Genomic Proteomic       Date:  2007-08-13

Review 10.  Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae.

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  43 in total

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Journal:  Nat Rev Drug Discov       Date:  2015-01-23       Impact factor: 84.694

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Journal:  Chem Res Toxicol       Date:  2019-10-16       Impact factor: 3.739

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Journal:  Nucleic Acids Res       Date:  2014-05-03       Impact factor: 16.971

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7.  Chemogenomic study of gemcitabine using Saccharomyces cerevisiae as model cell-molecular insights about chemoresistance.

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Journal:  Braz J Microbiol       Date:  2019-09-12       Impact factor: 2.476

8.  Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.

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10.  Chemical genomic screening of a Saccharomyces cerevisiae genomewide mutant collection reveals genes required for defense against four antimicrobial peptides derived from proteins found in human saliva.

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