Literature DB >> 6781726

Effects of 1 alpha-hydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 on bone remodeling.

K Galus, J Szymendera, A Zaleski, K Schreyer.   

Abstract

The present study was undertaken to evaluate the effects of 1 alpha-hydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 on bone remodeling in dogs with osteomalacia induced by vitamin D depletion. To assess the rates of skeletal remodeling, intravital tetracycline labeling and morphometry of surface pattern were employed. Either vitamin D3 derivative accelerated the appositional growth rate, increased the percentage of osteoid seams labeled, and decreased the number, width, and perimeter of new osteoid seams. But the derivatives differed in bone resorbing activity: 1 alpha-hydroxyvitamin D3 increased the number and perimeter of resorption sites whereas 24R,25-dihydroxyvitamin D3 decreased them. Thus the results show that the former is a better bone remodeler while the latter may be useful in treating osteoporosis.

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Year:  1980        PMID： 6781726     DOI： 10.1007/BF02407183

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  18 in total

1.  Bone resorbing activities of 24-hydroxy stereoisomers of 24-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.

Authors:  P H Stern; H F DeLuca; N Ikekawa
Journal:  Biochem Biophys Res Commun       Date:  1975-12-01       Impact factor: 3.575

2.  [Diagnostic value of assessing the rate of bone tissue layer formation on the intraosseous surfaces of rib and iliac cortical bone].

Authors:  K Galus; E Lok; Z Jaworski
Journal:  Pol Arch Med Wewn       Date:  1975-12

3.  The essentiality of vitamin D metabolites for embryonic chick development.

Authors:  M L Sunde; C M Turk; H F DeLuca
Journal:  Science       Date:  1978-06-02       Impact factor: 47.728

4.  Effects of 1 alpha,25-, 24R,25-, and 1 alpha,24R,25-hydroxylated metabolites of vitamin D3 on calcium and phosphate absorption by duodenum from intact and nephrectomized rats.

Authors:  M W Walling; D L Hartenbower; J W Coburn; A W Norman
Journal:  Arch Biochem Biophys       Date:  1977-07       Impact factor: 4.013

Review 5.  Basic and clinical concepts related to vitamin D metabolism and action (first of two parts).

Authors:  M R Haussler; T A McCain
Journal:  N Engl J Med       Date:  1977-11-03       Impact factor: 91.245

6.  The rate of osteoclastic bone erosion in Haversian remodeling sites of adult dog's rib.

Authors:  Z F Jaworski; E Lok
Journal:  Calcif Tissue Res       Date:  1972

7.  Effect of 24,25-dihydroxycholecalciferol on calcium absorption in proximal small intestine in uraemia.

Authors:  J Szymendera; K Galus
Journal:  Br Med J       Date:  1978-11-25

8.  The action of vitamin D metabolites (25 OHD3--12,5 (OH)2D3--24.25 (OH)2D3--25.26 (OH)2D3) on vitamin D deficient rats.

Authors:  M L Queille; L Miravet; P Bordier; J Redel
Journal:  Biomedicine       Date:  1978 Jul-Aug

9.  24, 25-dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation.

Authors:  A Ornoy; D Goodwin; D Noff; S Edelstein
Journal:  Nature       Date:  1978-11-30       Impact factor: 49.962

10.  Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?

Authors:  J A Kanis; T Cundy; M Bartlett; R Smith; G Heynen; G T Warner; R G Russell
Journal:  Br Med J       Date:  1978-05-27
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  9 in total

1.  Vitamin D endocrine system and osteoblasts.

Authors:  Marjolein van Driel; Johannes P T M van Leeuwen
Journal:  Bonekey Rep       Date:  2014-02-05

2.  Differentiation of Dihydroxylated Vitamin D3 Isomers Using Tandem Mass Spectrometry.

Authors:  Anisha Haris; Yuko P Y Lam; Christopher A Wootton; Alina Theisen; Bryan P Marzullo; Pascal Schorr; Dietrich A Volmer; Peter B O'Connor
Journal:  J Am Soc Mass Spectrom       Date:  2022-05-13       Impact factor: 3.262

3.  24,25(OH)2D3, bone formation, and bone resorption in vitamin D-deficient, azotemic rats.

Authors:  W G Goodman; D J Baylink; D J Sherrard
Journal:  Calcif Tissue Int       Date:  1984-03       Impact factor: 4.333

4.  Effects of 1,25-dihydroxycholecalciferol on fracture healing. Calcium, phosphate, and zinc in callus and serum.

Authors:  O Andreen; S E Larsson
Journal:  Arch Orthop Trauma Surg       Date:  1984

5.  Calcitriol but no other metabolite of vitamin D is essential for normal bone growth and development in the rat.

Authors:  A M Parfitt; C H Mathews; R Brommage; K Jarnagin; H F DeLuca
Journal:  J Clin Invest       Date:  1984-02       Impact factor: 14.808

6.  Autoradiographic localization of target cells for 1 alpha, 25-dihydroxyvitamin D3 in bones from fetal rats.

Authors:  R Narbaitz; W E Stumpf; M Sar; S Huang; H F DeLuca
Journal:  Calcif Tissue Int       Date:  1983       Impact factor: 4.333

7.  Interactions between calciotropic hormones.

Authors:  J N Bradbeer
Journal:  J R Soc Med       Date:  1987-08       Impact factor: 5.344

Review 8.  Vitamin D and gene networks in human osteoblasts.

Authors:  Jeroen van de Peppel; Johannes P T M van Leeuwen
Journal:  Front Physiol       Date:  2014-04-09       Impact factor: 4.566

9.  Effects of 1,25(OH)2 D3 and 25(OH)D3 on C2C12 Myoblast Proliferation, Differentiation, and Myotube Hypertrophy.

Authors:  K van der Meijden; N Bravenboer; N F Dirks; A C Heijboer; M den Heijer; G M J de Wit; C Offringa; P Lips; R T Jaspers
Journal:  J Cell Physiol       Date:  2016-04-14       Impact factor: 6.384
  9 in total

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