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Literature DB >> 647302

Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?

J A Kanis, T Cundy, M Bartlett, R Smith, G Heynen, G T Warner, R G Russell.

Abstract

Small doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite of vitamin D of uncertain function, increased intestinal absorption of calcium in normal people and in patients with various disorders or mineral metabolism, including anephric subjects. In five of six patients studied, calcium balance increased, but, unlike 1,25-dihydroxycholecalciferol, 24,25-(OH)2D3 did not increase plasma or urinary calcium concentrations. These results suggest that 24,25-(OH)2D3 may be an important regulator of skeletal metabolism in man with potential value as a therapeutic agent.

Entities: Chemical Disease Species

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Year: 1978 PMID： 647302 PMCID： PMC1604777 DOI： 10.1136/bmj.1.6124.1382

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

22 in total

1. A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma.

Authors: J A Eisman; A J Hamstra; B E Kream; H F DeLuca
Journal: Arch Biochem Biophys Date: 1976-09 Impact factor: 4.013

2. Determination of stereochemical configuration of the 24-hydroxyl group of 24,25-dihydroxyvitamin D3 and its biological importance.

Authors: Y Tanaka; H F DeLuca; N Ikekawa; M Morisaki; N Koizumi
Journal: Arch Biochem Biophys Date: 1975-10 Impact factor: 4.013

3. Advances in vitamin D metabolism as they pertain to chronic renal disease.

Authors: J W Coburn; D L Hartenbower; A S Brickman
Journal: Am J Clin Nutr Date: 1976-11 Impact factor: 7.045

4. Relative activities of some metabolites and analogs of cholecalciferol in stimulation of tibia ash weight in chicks otherwise deprived of vitamin D.

Authors: A Boris; J F Hurley; T Trmal
Journal: J Nutr Date: 1977-02 Impact factor: 4.798

Review 5. Regulation of vitamin D metabolism in the kidney.

Authors: H F DeLuca
Journal: Adv Exp Med Biol Date: 1977 Impact factor: 2.622

Review 6. Interrelationships between the key elements of the vitamin D endocrine system: 25-OH-D3-1-hydroxylase, serum calcium and phosphorus levels, intestinal 1,25(OH)2D3, and intestinal calcium binding protein.

Authors: A W Norman; E J Friedlander; H Henry
Journal: Adv Exp Med Biol Date: 1977 Impact factor: 2.622

10. Serum 25 (OH) D and 24,25 (OH)2 levels in childhood nephrosis under different therapeutic regimens of steroid administration.

Authors: K Kano; T Suda
Journal: Eur J Pediatr Date: 1982-03 Impact factor: 3.183

Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?

1. A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma.

2. Determination of stereochemical configuration of the 24-hydroxyl group of 24,25-dihydroxyvitamin D3 and its biological importance.

3. Advances in vitamin D metabolism as they pertain to chronic renal disease.

4. Relative activities of some metabolites and analogs of cholecalciferol in stimulation of tibia ash weight in chicks otherwise deprived of vitamin D.

Review 5. Regulation of vitamin D metabolism in the kidney.

Review 6. Interrelationships between the key elements of the vitamin D endocrine system: 25-OH-D3-1-hydroxylase, serum calcium and phosphorus levels, intestinal 1,25(OH)2D3, and intestinal calcium binding protein.

7. Inhibition of vitamin D metabolism by ethane-1-hydroxyl-1, 1-diphosphonate.

8. Failure of formation of 1,25-dihydroxycholecalciferol in chronic renal insufficiency.

9. Rate of reversal of hypercalcaemia and hypercalciuria induced by vitamin D and its 1alpha-hydroxylated derivatives.

10. 1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.

Review 1. Is 24,25(OH)D level really high in dialysis patients with high FGF23 levels?

2. Stimulation of undermineralized matrix formation by 1,25 dihydroxyvitamin D3 in long bones of rats.

3. 24,25-Dihydroxycholecalciferol and calcium absorption in uraemia.

4. Effects of 1,25- and 24,25-dihydroxyvitamin D3 on bone formation in the cichlid teleost Sarotherodon mossambicus.

5. Effects of vitamin D metabolites and analogs on bone collagen synthesis in vitro.

6. A monolog on analogs: in vitro effects of vitamin D metabolites and consideration of the mineralization question.

7. Serum 24,25-dihydroxyvitamin D and 25-hydroxyvitamin D concentrations in femoral neck fracture.

8. 24,25(OH)2D3, bone formation, and bone resorption in vitamin D-deficient, azotemic rats.

Review 9. Is there a role for vitamin D in osteoporosis?

10. Serum 25 (OH) D and 24,25 (OH)2 levels in childhood nephrosis under different therapeutic regimens of steroid administration.