| Literature DB >> 6548905 |
Abstract
The incorporation of calcium, phosphate, and zinc into the callus of closed tibial fractures was studied in adult rats fed a standard diet. Low doses (60 ng/kg per day) of 1,25(OH)2D3 5 days a week greatly increased early callus mineralization. This was not related to an increased serum calcium-phosphate molar product but rather to a decreased ratio. The incorporation of zinc into callus seemed to be correlated to the mineralization process but not to the 1,25(OH)2D3 administration as such. The question of a direct, indirect, or a complex role of 1,25(OH)2D3 in bone formation and mineralization is discussed.Entities:
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Year: 1984 PMID： 6548905 DOI： 10.1007/bf00387331
Source DB: PubMed Journal: Arch Orthop Trauma Surg ISSN： 0344-8444