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Literature DB >> 6781013

Flavonoids and related compounds as inhibition of arachidonic acid peroxidation.

Abstract

Until now only few data have been reported on biochemically explicable pharmacological effects of flavonoid structures. When tested against arachidonic acid metabolism many flavonoids were found to be effective against the lipoxygenase and cyclo-oxygenase pathways. Some flavonoids were predominant inhibitors of either cyclo-oxygenase or lipoxygenase, others were equally effective against both enzymes. Therefore, these compounds proved to be useful tools to elucidate fatty acid peroxidation problems.

Entities: Chemical

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Year: 1980 PMID： 6781013 DOI： 10.1016/0090-6980(80)90103-3

Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980

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Cited

30 in total

Review 1. The nutritional incidence of flavonoids: some physiological and metabolic considerations.

Authors: C R Roger
Journal: Experientia Date: 1988-09-15

2. The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.

Authors: W Kreutner; J Sherwood; C Rizzo
Journal: Agents Actions Date: 1989-11

3. In vitro and in vivo effects of genistein on murine alveolar macrophage TNF alpha production.

Authors: P E Morris; L E Olmstead; A E Howard-Carroll; G R Dickens; M L Goltz; C Courtney-Shapiro; P Fanti
Journal: Inflammation Date: 1999-06 Impact factor: 4.092

4. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.

Authors: M E Gerritsen; W W Carley; G E Ranges; C P Shen; S A Phan; G F Ligon; C A Perry
Journal: Am J Pathol Date: 1995-08 Impact factor: 4.307

5. Strong activation of cyclooxygenase I and II catalytic activity by dietary bioflavonoids.

Authors: Hyoung-Woo Bai; Bao Ting Zhu
Journal: J Lipid Res Date: 2008-07-26 Impact factor: 5.922

6. Antimalarial efficacy, cytotoxicity, and genotoxicity of methanolic stem bark extract from Hintonia latiflora in a Plasmodium yoelii yoelii lethal murine malaria model.

Authors: Norma Rivera; Perla Y López; Marcela Rojas; Teresa I Fortoul; Diana Y Reynada; Alberto J Reyes; Ernesto Rivera; Hiram I Beltrán; Filiberto Malagón
Journal: Parasitol Res Date: 2014-02-19 Impact factor: 2.289

Flavonoids and related compounds as inhibition of arachidonic acid peroxidation.

Review 1. The nutritional incidence of flavonoids: some physiological and metabolic considerations.

2. The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.

3. In vitro and in vivo effects of genistein on murine alveolar macrophage TNF alpha production.

4. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.

5. Strong activation of cyclooxygenase I and II catalytic activity by dietary bioflavonoids.

6. Antimalarial efficacy, cytotoxicity, and genotoxicity of methanolic stem bark extract from Hintonia latiflora in a Plasmodium yoelii yoelii lethal murine malaria model.

7. Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality.

Review 8. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.

9. Influence of rhein anthrone on peristaltic reflex of guinea-pig isolated ileum: involvement of prostaglandins.

10. Effect of antihepatotoxic agents against microcystin-LR toxicity in cultured rat hepatocytes.