Literature DB >> 1902564

Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality.

K A Mereish1, D L Bunner, D R Ragland, D A Creasia.   

Abstract

Microcystin-LR, a cyclic heptapeptide synthesized by the blue-green algae, Microcystis aeruginosa, is a potent hepatotoxin. Pathological examination of livers from mice and rats that received microcystin-LR revealed severe, peracute, diffuse, centrilobular hepatocellular necrosis, and hemorrhage. These changes were correlated with increased serum activities of sorbitol dehydrogenase, alanine aminotransferase, and lactate dehydrogenase. Pretreatment of either rats or mice with a single dose of silymarin, a flavonolignane isolated from the wild artichoke (Silybum marianum L. Gaertn), completely abolished the lethal effects, pathological changes, and significantly decreased the levels of serum enzymes induced by microcystin-LR intoxication.

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Year:  1991        PMID： 1902564     DOI： 10.1023/a:1015868809990

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  17 in total

1.  Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers.

Authors:  J Sonnenbichler; I Zetl
Journal:  Prog Clin Biol Res       Date:  1986

2.  Technique for cardiovascular monitoring in awake tethered rats.

Authors:  G W Parker; D G Martin
Journal:  Lab Anim Sci       Date:  1989-09

3.  Pathophysiology of cyanoginosin-LR: in vivo and in vitro studies.

Authors:  W H Adams; J P Stone; B Sylvester; R D Stoner; D N Slatkin; N R Tempel; H W Siegelman
Journal:  Toxicol Appl Pharmacol       Date:  1988-11       Impact factor: 4.219

4.  Effects of the peptide toxin from Microcystis aeruginosa on intracellular calcium, pH and membrane integrity in mammalian cells.

Authors:  I R Falconer; M T Runnegar
Journal:  Chem Biol Interact       Date:  1987       Impact factor: 5.192

5.  Comparison of in vivo and in vitro toxic effects of microcystin-LR in fasted rats.

Authors:  G A Miura; N A Robinson; T W Geisbert; K A Bostian; J D White; J G Pace
Journal:  Toxicon       Date:  1989       Impact factor: 3.033

6.  Toxicity of microcystin LR, a cyclic heptapeptide hepatotoxin from Microcystis aeruginosa, to rats and mice.

Authors:  S B Hooser; V R Beasley; R A Lovell; W W Carmichael; W M Haschek
Journal:  Vet Pathol       Date:  1989-05       Impact factor: 2.221

7.  Effect of antihepatotoxic agents against microcystin-LR toxicity in cultured rat hepatocytes.

Authors:  K A Mereish; R Solow
Journal:  Pharm Res       Date:  1990-03       Impact factor: 4.200

8.  Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation.

Authors:  A Valenzuela; R Guerra
Journal:  Experientia       Date:  1986-02-15

9.  Pathophysiologic effects of a toxic peptide from Microcystis aeruginosa.

Authors:  W H Adams; R D Stoner; D G Adams; D N Slatkin; H W Siegelman
Journal:  Toxicon       Date:  1985       Impact factor: 3.033

10.  Atypical pulmonary thrombosis caused by a toxic cyanobacterial peptide.

Authors:  D N Slatkin; R D Stoner; W H Adams; J H Kycia; H W Siegelman
Journal:  Science       Date:  1983-06-24       Impact factor: 47.728
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  20 in total

1.  Comparison of the prophylactic effect of silymarin and deferoxamine on iron overload-induced hepatotoxicity in rat.

Authors:  Hossein Najafzadeh; Mohammad Razi Jalali; Hassan Morovvati; Farnaz Taravati
Journal:  J Med Toxicol       Date:  2010-03

Review 2.  Molecular mechanisms of inhibition of photocarcinogenesis by silymarin, a phytochemical from milk thistle (Silybum marianum L. Gaertn.) (Review).

Authors:  Mudit Vaid; Santosh K Katiyar
Journal:  Int J Oncol       Date:  2010-05       Impact factor: 5.650

3.  Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.

Authors:  Kameswaran Ravichandran; Balaiya Velmurugan; Mallikarjuna Gu; Rana P Singh; Rajesh Agarwal
Journal:  Clin Cancer Res       Date:  2010-09-07       Impact factor: 12.531

4.  Treatment of cyanobacterial (microcystin) toxicosis using oral cholestyramine: case report of a dog from Montana.

Authors:  Kelly A Rankin; Karen A Alroy; Raphael M Kudela; Stori C Oates; Michael J Murray; Melissa A Miller
Journal:  Toxins (Basel)       Date:  2013-06       Impact factor: 4.546

5.  Silibinin enhances ultraviolet B-induced apoptosis in mcf-7 human breast cancer cells.

Authors:  Eun-Mi Noh; Mi Suk Yi; Hyun Jo Youn; Byoung Kil Lee; Young-Rae Lee; Ji-Hey Han; Hong-Nu Yu; Jong-Suk Kim; Sung Hoo Jung
Journal:  J Breast Cancer       Date:  2011-03-31       Impact factor: 3.588

6.  Synergistic antibacterial effect between silibinin and antibiotics in oral bacteria.

Authors:  Young-Soo Lee; Kyeung-Ae Jang; Jeong-Dan Cha
Journal:  J Biomed Biotechnol       Date:  2011-09-15

7.  The treatment of melasma by silymarin cream.

Authors:  Tagreed Altaei
Journal:  BMC Dermatol       Date:  2012-10-02

8.  Microcystic cyanobacteria causes mitochondrial membrane potential alteration and reactive oxygen species formation in primary cultured rat hepatocytes.

Authors:  W X Ding; H M Shen; Y Shen; H G Zhu; C N Ong
Journal:  Environ Health Perspect       Date:  1998-07       Impact factor: 9.031

9.  Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-κB Pathway.

Authors:  Eun Jeong Kim; Min Young Lee; Young Jin Jeon
Journal:  Korean J Physiol Pharmacol       Date:  2015-04-30       Impact factor: 2.016

Review 10.  Canine cyanotoxin poisonings in the United States (1920s-2012): review of suspected and confirmed cases from three data sources.

Authors:  Lorraine C Backer; Jan H Landsberg; Melissa Miller; Kevin Keel; Tegwin K Taylor
Journal:  Toxins (Basel)       Date:  2013-09-24       Impact factor: 4.546
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