Literature DB >> 6777100

Specificities of antibody to acetylcholine receptor in rabbits with experimental myasthenia gravis.

S Ueno, J Kang, H Takeuchi, M Takahashi, S Tarui.   

Abstract

The injection of acetylcholine receptor (AChR) purified from Narke electroplax japonica induced 'experimental autoimmune myasthenia gravis' (EAMG) in rabbits. Serial measurements of anti-AChR antibody titre using Narke AChR and rabbit AChR as antigen revealed that the intensity of myasthenia had a rather closer correlation with titre to Narke AChR than that to rabbit AChR. Antibody reacting to rabbit AChR was almost completely adsorbed out with torpedo receptor conjugated to agarose. Serum concentrations of antibody protein measured by affinity chromatography ranged from 54 to 896 microgram/ml serum and were well correlated with the intensity of myasthenia. The results suggested that in rabbits immunized with heterologous AChR the cross-reaction of anti-heterologous AChR antibody with rabbit AChR caused myasthenia rather than an immune response specific to rabbit AChR dose.

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Year:  1980        PMID： 6777100      PMCID： PMC1536913     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  11 in total

1.  Strain differences in the autoimmune response of mice to acetylcholine receptors.

Authors:  S Fuchs; D Nevo; R Tarrab-Hazdai; I Yaar
Journal:  Nature       Date:  1976-09-23       Impact factor: 49.962

2.  Experimental myasthenia in rabbits: biochemical, immunological, electrophysiological, and morphological aspects.

Authors:  E Heilbronn; C Mattsson; L E Thornell; M Sjöström; E Stålberg; P Hilton-Brown; D Elmqvist
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

3.  Neuromuscular transmission after immunization against acetylcholine receptors.

Authors:  D P Green; R Miledi; A Vincent
Journal:  Proc R Soc Lond B Biol Sci       Date:  1975-04-29

4.  Autoimmune response to acetylcholine receptor.

Authors:  J Patrick; J Lindstrom
Journal:  Science       Date:  1973-05-25       Impact factor: 47.728

5.  Selective enzyme purification by affinity chromatography.

Authors:  P Cuatrecasas; M Wilchek; C B Anfinsen
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

6.  Immunochemical studies on acetylcholine receptor from Torpedo californica.

Authors:  A Aharonov; R Tarrab-Hazdai; I Silman; S Fuchs
Journal:  Immunochemistry       Date:  1977-02

7.  Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus.

Authors:  H Sugiyama; P Benda; J C Meunier; J P Changeux
Journal:  FEBS Lett       Date:  1973-09-01       Impact factor: 4.124

8.  Experimental autoimmune myasthenia gravis and myasthenia gravis: biochemical and immunochemical aspects.

Authors:  J M Lindstrom; V A Lennon; M E Seybold; S Whittingham
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

Review 9.  Immunology of the acetylcholine receptor.

Authors:  V A Lennon
Journal:  Immunol Commun       Date:  1976

10.  Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.

Authors:  V A Lennon; J M Lindstrom; M E Seybold
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307
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  2 in total

1.  Suitable hollow fibre immunobioreactors for specific ex vivo removal of antibodies and antigens from plasma.

Authors:  C Larue; V Gueraud; C Rivat
Journal:  Clin Exp Immunol       Date:  1985-10       Impact factor: 4.330

2.  Acetylcholine receptor in rabbit thymus: antigenic similarity between acetylcholine receptors of muscle and thymus.

Authors:  S Ueno; K Wada; M Takahashi; S Tarui
Journal:  Clin Exp Immunol       Date:  1980-12       Impact factor: 4.330
  2 in total

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