Literature DB >> 6774884

Effects of repeated administration of potassium canrenoate (SC-14266) on serum gonadotrophin, prolactin, testosterone and progesterone in male rats.

T Muraki, T Nakadate, K Kubota, Y Tokunaga, R Kato.   

Abstract

Chronic administration of potassium canrenoate (SC-14266), a water-soluble anti-aldosterone agent, increased serum LH levels in male rats without altering serum levels of FSH, prolactin, testosterone and progesterone. The increase in serum LH may be due to the anti-androgenic effect of potassium canrenoate.

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Year:  1980        PMID： 6774884     DOI： 10.1007/bf01970128

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Effect of spironolactone on sex hormones in man.

Authors:  B Stripp; A A Taylor; F C Bartter; J R Gillette; D L Loriaux; R Easley; R H Menard
Journal:  J Clin Endocrinol Metab       Date:  1975-10       Impact factor: 5.958

2.  Suppression by the spironolactone metabolite canrenone of plasma testosterone in man.

Authors:  H C Erbler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

3.  Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism.

Authors:  R H Menard; B Stripp; J R Gillette
Journal:  Endocrinology       Date:  1974-06       Impact factor: 4.736

4.  Antiandrogenic effect of spironolactone in rats.

Authors:  G T Basinger; R F Gittes
Journal:  J Urol       Date:  1974-01       Impact factor: 7.450

5.  The effect of Soldactona (canrenoate-potassium) on plasma testosterone and androstenedione and urinary 17-ketosteroids and 17-hydroxycorticosteroids.

Authors:  J F Dymling; K O Nilsson; B Hökfelt
Journal:  Acta Endocrinol (Copenh)       Date:  1972-05

6.  Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7alpha-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450.

Authors:  R H Menard; T M Guenthner; H Kon; J R Gillette
Journal:  J Biol Chem       Date:  1979-03-10       Impact factor: 5.157

7.  Effect of narcotic analgesics and naloxone on proestrous surges of LH, FSH and prolactin in rats.

Authors:  T Muraki; H Nakadate; Y Tokunaga; R Kato; T Makino
Journal:  Neuroendocrinology       Date:  1979       Impact factor: 4.914

8.  Spironolactone stimulation of gonadotropin secretion in boys with delayed adolescence.

Authors:  R J Santen; H E Kulin; D L Loriaux; J Friend
Journal:  J Clin Endocrinol Metab       Date:  1976-12       Impact factor: 5.958

9.  Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate.

Authors:  P C Walsh; P K Siiteri
Journal:  J Urol       Date:  1975-08       Impact factor: 7.450

10.  Antiandrogenic effects of spironolactone: hormonal and ultrastructural studies in dogs and men.

Authors:  S Baba; M Murai; S Jitsukawa; M Hata; H Tazaki
Journal:  J Urol       Date:  1978-03       Impact factor: 7.450
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