| Literature DB >> 642094 |
S Baba, M Murai, S Jitsukawa, M Hata, H Tazaki.
Abstract
A decrease in the level of plasma testosterone and an increase in the level of plasma progesterone were noted after spironolactone had been administered for 20 days in 5 patients with prostatic carcinoma, as well as in 8 male dogs. Electron microscopic observation disclosed myelin-like bodies in the cytoplasm of Leydig and adrenocortical cells in dogs, contributing to a resolution of the mode of antiandrogenic action of spironolactone.Entities:
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Year: 1978 PMID： 642094 DOI： 10.1016/s0022-5347(17)57495-9
Source DB: PubMed Journal: J Urol ISSN： 0022-5347 Impact factor: 7.450