Literature DB >> 6771754

Identification of prosomatostatin in pancreatic islets.

C Patzelt, H S Tager, R J Carroll, D F Steiner.   

Abstract

A 12.5-kilodalton protein not related to insulin or glucagon was detected in pulse-chase-labeled rat islets of Langerhans. Although this protein reacted poorly with various somatostatin antisera, analysis of two-dimensional peptide maps showed that it contains all of the tryptic fragments of somatostatin, which is located at its COOH terminus. Proteolytic conversion of the putative prosomatostatin, which took place parallel to the processing of proinsulin and proglucagon in pulse-chase experiments, coincided with the appearance of newly synthesized somatostatin and proceeded without the apparent involvement of major intermediate forms.

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Year:  1980        PMID： 6771754      PMCID： PMC349408          DOI： 10.1073/pnas.77.5.2410

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Letter: Immunohistochemical localization of somatostatin in the rat pancreas.

Authors:  G Pelletier; R Leclerc; A Arimura; A V Schally
Journal:  J Histochem Cytochem       Date:  1975-09       Impact factor: 2.479

2.  Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.

Authors:  M P Dubois
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

3.  Immunohistochemical evidence for the localization of somatostatin--like immunoreactivity in a cell population of the pancreatic islets.

Authors:  R Luft; S Efendic; T Hökfelt; O Johansson; A Arimura
Journal:  Med Biol       Date:  1974-12

4.  Cellular localization of gastrin in the human pancreas.

Authors:  M H Greider; J E McGuigan
Journal:  Diabetes       Date:  1971-06       Impact factor: 9.461

5.  Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate.

Authors:  R T Swank; K D Munkres
Journal:  Anal Biochem       Date:  1971-02       Impact factor: 3.365

6.  Immunohistochemical demonstration of gastrin in mammalian islets of Langerhans.

Authors:  R Lomský; F Langer; V Vortel
Journal:  Nature       Date:  1969-08-09       Impact factor: 49.962

7.  Method for the isolation of intact islets of Langerhans from the rat pancreas.

Authors:  P E Lacy; M Kostianovsky
Journal:  Diabetes       Date:  1967-01       Impact factor: 9.461

8.  Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells.

Authors:  J M Polak; A G Pearse; L Grimelius; S R Bloom
Journal:  Lancet       Date:  1975-05-31       Impact factor: 79.321

9.  Calcemic fraction-A: biosynthetic peptide precursor of parathyroid hormone.

Authors:  D V Cohn; R R Macgregor; L L Chu; J R Kimmel; J W Hamilton
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

10.  Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.

Authors:  P Brazeau; W Vale; R Burgus; N Ling; M Butcher; J Rivier; R Guillemin
Journal:  Science       Date:  1973-01-05       Impact factor: 47.728
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  15 in total

1.  Normal development of cells with somatostatin immunoreactivity in the pancreas and duodenum of the rat fetus and newborn. Effect of hypophysectomy and intrauterine growth retardation.

Authors:  J P Dupouy; A Chatelain; M P Dubois
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249

2.  A high molecular weight form of somatostatin-28 (1-12)-like immunoreactive substance without somatostatin-14 immunoreactivity in the rat pancreas. Evidence that somatostatin-14 synthesis can occur independently of somatostatin-28.

Authors:  Y C Patel
Journal:  J Clin Invest       Date:  1983-12       Impact factor: 14.808

3.  Cell-free biosynthesis of somatostatin precursors: Evidence for multiple forms of preprosomatostatin.

Authors:  T G Warren; D Shields
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

Review 4.  Multiple forms of gastroenteropancreatic hormones.

Authors:  G B Irvine; R F Murphy
Journal:  Gut       Date:  1981-12       Impact factor: 23.059

5.  Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.

Authors:  C Patzelt; E Schiltz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

6.  Identification and localization of glucagon-related peptides in rat brain.

Authors:  H Tager; M Hohenboken; J Markese; R J Dinerstein
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

7.  Human somatostatin I: sequence of the cDNA.

Authors:  L P Shen; R L Pictet; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

8.  Differential inhibitory action of cationic amino acids on protein synthesis in pancreatic rat islets.

Authors:  C Patzelt
Journal:  Diabetologia       Date:  1988-04       Impact factor: 10.122

9.  Sequence analysis of a cDNA coding for a pancreatic precursor to somatostatin.

Authors:  W L Taylor; K J Collier; R J Deschenes; H L Weith; J E Dixon
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

10.  Immunocytochemical localization of prosomatostatin fragments in maturing and mature secretory granules of pancreatic and gastrointestinal D cells.

Authors:  M Ravazzola; R Benoit; N Ling; R Guillemin; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205
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