Literature DB >> 4682131

Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.

P Brazeau, W Vale, R Burgus, N Ling, M Butcher, J Rivier, R Guillemin.   

Abstract

A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.

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Year:  1973        PMID： 4682131     DOI： 10.1126/science.179.4068.77

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  532 in total

1.  Distribution, targeting, and internalization of the sst4 somatostatin receptor in rat brain.

Authors:  M Schreff; S Schulz; M Händel; G Keilhoff; H Braun; G Pereira; M Klutzny; H Schmidt; G Wolf; V Höllt
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

Review 2.  A history of acromegaly.

Authors:  R Sheaves
Journal:  Pituitary       Date:  1999-06       Impact factor: 4.107

3.  Immuno-fluorescent reactivity to anti-somatostatin in the gastro-intestinal mucosa of the dog.

Authors:  C Rufener; M P Dubois; F Malaisse Lagae; L Oric
Journal:  Diabetologia       Date:  1975-08       Impact factor: 10.122

4.  Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.

Authors:  M P Dubois
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

5.  Somatostatin release by glutamate in vivo is primarily regulated by AMPA receptors.

Authors:  G J Hathway; P P Humphrey; K M Kendrick
Journal:  Br J Pharmacol       Date:  2001-11       Impact factor: 8.739

6.  Somatostatin analogues: are they analogues of somatostatin?

Authors:  R Deghenghi
Journal:  J Endocrinol Invest       Date:  2002-04       Impact factor: 4.256

Review 7.  The epidural and intrathecal administration of somatotrophin-release inhibiting factor: native and synthetic analogues.

Authors:  D P Beltrutti; S Moessinger; G Varrassi
Journal:  Curr Rev Pain       Date:  2000

8.  Neuroendocrine control of growth hormone secretion.

Authors:  E Müller
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977       Impact factor: 3.000

9.  Effects of synthetic somatostatin on endotoxin-induced changes of growth hormone, cortisol and insulin in plasma, blood sugar and blood leukocytes in man.

Authors:  H Wagner; E Zierden; W H Hauss
Journal:  Klin Wochenschr       Date:  1975-06-01

10.  Growth hormone-release inhibiting hormone (GH-RIH) pathway of the rat hypothalamus revealed by the unlabeled antibody peroxidase-antiperoxidase method.

Authors:  J C King; A A Gerall; J B Fishback; K E Elkind
Journal:  Cell Tissue Res       Date:  1975-07-23       Impact factor: 5.249
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