Literature DB >> 6771749

Baclofen overdose.

D J Lipscomb, T J Meredith.   

Abstract

A 57-year-old woman suffering from multiple sclerosis took an estimated 1500 mg of baclofen. She became deeply unconscious with generalized flaccid muscle paralysis and absent tendon reflexes. Toxicological analysis confirmed the presence of baclofen together with small amounts of paracetamol and glutethimide. Supportive therapy, including assisted ventilation for 3 days, led to complete recovery; anticonvulsant drugs were necessary for the treatment of grand mal fits. The clinical features and treatment of baclofen overdose are discussed.

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Year:  1980        PMID： 6771749      PMCID： PMC2425514          DOI： 10.1136/pgmj.56.652.108

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  6 in total

1.  Lioresal in the treatment of spinal spasticity.

Authors:  V Paeslack
Journal:  Postgrad Med J       Date:  1972-10       Impact factor: 2.401

2.  Pharmacological aspects of spasticity with special reference to Lioresal.

Authors:  W P Koella
Journal:  Postgrad Med J       Date:  1972-10       Impact factor: 2.401

3.  Routine analysis of barbiturates and some other hypnotic drugs in the blood plasma as an aid to the diagnosis of acute poisoning.

Authors:  R J Flanagan; D J Berry
Journal:  J Chromatogr       Date:  1977-01-21

4.  Letter: paracetamol measurement.

Authors:  J P Glynn; S E Kendal
Journal:  Lancet       Date:  1975-05-17       Impact factor: 79.321

5.  The determination of gamma-amino-beta-(p-chlorophenyl)butyric acid (baclofen) in biological material by gas-liquid chromatography.

Authors:  P H Degen; W Riess
Journal:  J Chromatogr       Date:  1976-02-18

6.  Overdose of lioresal.

Authors:  G W Paulson
Journal:  Neurology       Date:  1976-11       Impact factor: 9.910
  6 in total
  10 in total

1.  Drug points: Neonatal convulsions after withdrawal of baclofen.

Authors:  B D Ratnayaka; H Dhaliwal; S Watkin
Journal:  BMJ       Date:  2001-07-14

2.  Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature.

Authors:  Guido F Weißhaar; Marc Hoemberg; Katja Bender; Ursula Bangen; Peter Herkenrath; Frank Eifinger; Markus Rothschild; Bernhard Roth; André Oberthuer
Journal:  Eur J Pediatr       Date:  2012-06-23       Impact factor: 3.183

3.  Baclofen overdose treated with continuous venovenous hemofiltration.

Authors:  Didier Meulendijks; Saheed Khan; Cornelis H W Koks; Alwin D R Huitema; Jan H M Schellens; Jos H Beijnen
Journal:  Eur J Clin Pharmacol       Date:  2015-01-09       Impact factor: 2.953

4.  Baclofen-induced epilepsy.

Authors:  J M Rush; F B Gibberd
Journal:  J R Soc Med       Date:  1990-02       Impact factor: 5.344

Review 5.  Spasticity and drug therapy.

Authors:  E W Wuis
Journal:  Pharm Weekbl Sci       Date:  1987-10-16

6.  Baclofen overdose mimicking anoxic encephalopathy: a case report and review of the literature.

Authors:  John J Miller
Journal:  Ther Adv Drug Saf       Date:  2017-02-01

Review 7.  A benefit-risk assessment of baclofen in severe spinal spasticity.

Authors:  Alessandro Dario; Giustino Tomei
Journal:  Drug Saf       Date:  2004       Impact factor: 5.606

8.  Atropine treatment for baclofen overdose.

Authors:  R E Ferner
Journal:  Postgrad Med J       Date:  1981-09       Impact factor: 2.401

9.  Respiratory effects of baclofen and 3-aminopropylphosphinic acid in guinea-pigs.

Authors:  J A Hey; G Mingo; D C Bolser; W Kreutner; D Krobatsch; R W Chapman
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

Review 10.  Toxicologic Confounders of Brain Death Determination: A Narrative Review.

Authors:  Lauren Murphy; Hannah Wolfer; Robert G Hendrickson
Journal:  Neurocrit Care       Date:  2020-09-30       Impact factor: 3.532
  10 in total

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