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Literature DB >> 6769036

Rec assay and mutagenicity studies on metal compounds.

Abstract

We carried out rec assays on 127 metal compounds with Bacillus subtilis to check their DNA-damaging capacity and mutagenicity. Certain compounds of beryllium, cobalt, cesium, iridium, osmium, platinum, rhodium, antimony, tellurium, thallium and vanadium were newly found to be positive in addition to those of known positive metals such as arsenic, cadmium, chromium, mercury, molybdenum and selenium. Reverse mutation assays with Escherichia coli and Salmonella strains showed that compounds of rhodium (RhCl3), tellurium (Na2H4TeO6, Na2TeO3) and platinum (PtCl4, (NH4)2PtCl6) are potent mutagens.

Entities: Chemical Species

Mesh：

Substances：
Metals
Mutagens

Year: 1980 PMID： 6769036 DOI： 10.1016/0165-1218(80)90127-5

Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433

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Cited

18 in total

Review 1. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

Authors: Daniel Krewski; Robert A Yokel; Evert Nieboer; David Borchelt; Joshua Cohen; Jean Harry; Sam Kacew; Joan Lindsay; Amal M Mahfouz; Virginie Rondeau
Journal: J Toxicol Environ Health B Crit Rev Date: 2007 Impact factor: 6.393

2. Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?

Authors: M Goldman; J C Dacre
Journal: Environ Geochem Health Date: 1991-12 Impact factor: 4.609

3. Cyto- and genotoxic effects of coordination complexes of platinum, palladium and rhodium in vitro.

Authors: J Bünger; J Stork; K Stalder
Journal: Int Arch Occup Environ Health Date: 1996 Impact factor: 3.015

4. In vivo effects of mercury (II) on deoxyuridine triphosphate nucleotidohydrolase, DNA polymerase (alpha, beta), and uracil-DNA glycosylase activities in cultured human cells: relationship to DNA damage, DNA repair, and cytotoxicity.

Authors: M V Williams; T Winters; K S Waddell
Journal: Mol Pharmacol Date: 1987-02 Impact factor: 4.436

Rec assay and mutagenicity studies on metal compounds.

Review 1. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

2. Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?

3. Cyto- and genotoxic effects of coordination complexes of platinum, palladium and rhodium in vitro.

4. In vivo effects of mercury (II) on deoxyuridine triphosphate nucleotidohydrolase, DNA polymerase (alpha, beta), and uracil-DNA glycosylase activities in cultured human cells: relationship to DNA damage, DNA repair, and cytotoxicity.

5. Bacillus subtilis "rec assay" test with isogenic strains.

6. Nickel-induced heritable alterations in retroviral transforming gene expression.

7. Comparison of the clastogenic effects of antimony trioxide on mice in vivo following acute and chronic exposure.

8. In vitro studies on the DNA impairments induced by Cr(III) complexes with cellular reductants.

9. Transformation of prostatic epithelial cells and fibroblasts with cadmium chloride in vitro.

10. In vitro assessment of the toxicity of metal compounds : II. Mutagenesis.