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Literature DB >> 8148620

In vitro studies on the DNA impairments induced by Cr(III) complexes with cellular reductants.

B Gulanowski¹, M Cieślak-Golonka, K Szyba, J Urban.

Abstract

The influence of Cr(III) complexes with ascorbic acid, cysteine and glutathione on DNA has been studied spectrophotometrically and chromatographically. The toxic and genotoxic activities of these complexes were also investigated. It was found that these complexes bind to DNA weaker than hexaaqua Cr(III) complexes. It could be explained through the greater strength of the bi- and tridentate ligands coordinated to chromium in comparison to water molecules. The formation of DNA-DNA intermolecular bonds and DNA interstrand cross-linking has been also observed. These complexes were found to be non-toxic and non-genotoxic in the bacterial test.

Entities: Chemical

Mesh：

Substances：

Year: 1994 PMID： 8148620 DOI： 10.1007/bf00140489

Source DB: PubMed Journal: Biometals ISSN： 0966-0844 Impact factor: 2.949

25 in total

Review 1. Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis?

Authors: A M Standeven; K E Wetterhahn
Journal: Chem Res Toxicol Date: 1991 Nov-Dec Impact factor: 3.739

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Authors: H Hirano; T Nishimura; T Iwamura
Journal: Anal Biochem Date: 1985-10 Impact factor: 3.365

3. Effects of chromium(III) on DNA replication in vitro.

Authors: E T Snow; L S Xu
Journal: Biol Trace Elem Res Date: 1989 Jul-Sep Impact factor: 3.738

4. Influence of chromium compounds on microbial growth and nucleic acid synthesis.

Authors: T Ogawa; M Usui; C Yatome; E Idaka
Journal: Bull Environ Contam Toxicol Date: 1989-08 Impact factor: 2.151

5. Modification of chromium(VI)-induced DNA damage by glutathione and cytochromes P-450 in chicken embryo hepatocytes.

Authors: D Y Cupo; K E Wetterhahn
Journal: Proc Natl Acad Sci U S A Date: 1985-10 Impact factor: 11.205

6. Coordination chemistry of vitamin C. Part II. Interaction of L-ascorbic acid with Zn(II), Cd(II), Hg(II), and Mn(II) ions in the solid state and in aqueous solution.

Authors: H A Tajmir-Riahi
Journal: J Inorg Biochem Date: 1991-04 Impact factor: 4.155

In vitro studies on the DNA impairments induced by Cr(III) complexes with cellular reductants.

Review 1. Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis?

2. High-flow-rate hydroxylapatites.

3. Effects of chromium(III) on DNA replication in vitro.

4. Influence of chromium compounds on microbial growth and nucleic acid synthesis.

5. Modification of chromium(VI)-induced DNA damage by glutathione and cytochromes P-450 in chicken embryo hepatocytes.

6. Coordination chemistry of vitamin C. Part II. Interaction of L-ascorbic acid with Zn(II), Cd(II), Hg(II), and Mn(II) ions in the solid state and in aqueous solution.

7. Chromium cross-links glutathione and cysteine to DNA.

8. Mutagenicity of a series of hexacoordinate chromium (III) compounds.

9. DNA-protein complexes induced by chromate and other carcinogens.

10. Effects of vitamins on chromium(VI)-induced damage.

1. Can elevated chromium induce somatopsychic responses?