| Literature DB >> 6767729 |
Abstract
When the growth rate of the yeast Saccharomyces cerevisiae is limited with various nitrogen sources, the duration of the S phase is proportional to cell cycle length over a fourfold range of growth rates (C.J. Rivin and W. L. Fangman, 1980, J. Cell Biol. 85:96-107). Molecular parameters of the S phases of these cells were examined by DNA fiber autoradiography. Changes in replication fork rate account completely for the changes in S-phase duration. No changes in origin-to-origin distances were detected. In addition, it was found that while most adjacent replication origins are activated within a few minutes of each other, new activations occur throughout the S phase.Entities:
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Year: 1980 PMID: 6767729 PMCID: PMC2110590 DOI: 10.1083/jcb.85.1.108
Source DB: PubMed Journal: J Cell Biol ISSN: 0021-9525 Impact factor: 10.539