Literature DB >> 6767246

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

T Kataoka, T Kawakami, N Takahashi, T Honjo.   

Abstract

Cloning and nucleotide sequence determination suggest that the rearranged gamma 1-chain gene in a gamma 1-chain-producing myeloma a-pears to be formed by the recombination between the 5' flanking regions of the gamma 1- and mu-chain genes of undifferentiated cells. The recombination site is distinct from the putative J region and is a novel region that we call the S region. We have extended our previous model that explains the heavy-chain class switching by two or more successive recombination events.

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Year:  1980        PMID： 6767246      PMCID： PMC348393          DOI： 10.1073/pnas.77.2.919

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  A complete immunoglobulin gene is created by somatic recombination.

Authors:  C Brack; M Hirama; R Lenhard-Schuller; S Tonegawa
Journal:  Cell       Date:  1978-09       Impact factor: 41.582

2.  Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.

Authors:  H Sakano; J H Rogers; K Hüppi; C Brack; A Traunecker; R Maki; R Wall; S Tonegawa
Journal:  Nature       Date:  1979-02-22       Impact factor: 49.962

3.  The arrangement and rearrangement of antibody genes.

Authors:  J G Seidman; P Leder
Journal:  Nature       Date:  1978 Dec 21-28       Impact factor: 49.962

4.  High capacity gel preparative electrophoresis for purification of fragments of genomic DNA.

Authors:  F Polsky; M H Edgell; J G Seidman; P Leder
Journal:  Anal Biochem       Date:  1978-07-01       Impact factor: 3.365

5.  Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda.

Authors:  D C Tiemeier; S M Tilghman; P Leder
Journal:  Gene       Date:  1977       Impact factor: 3.688

6.  Organization of immunoglobulin heavy chain genes and allelic deletion model.

Authors:  T Honjo; T Kataoka
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

7.  Variable region genes for the immunoglobulin framework are assembled from small segments of DNA--a hypothesis.

Authors:  E A Kabat; T T Wu; H Bilofsky
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

8.  Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.

Authors:  K Adetugbo
Journal:  J Biol Chem       Date:  1978-09-10       Impact factor: 5.157

9.  Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.

Authors:  P W Early; M M Davis; D B Kaback; N Davidson; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

10.  Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

Authors:  F Bolivar; R L Rodriguez; P J Greene; M C Betlach; H L Heyneker; H W Boyer; J H Crosa; S Falkow
Journal:  Gene       Date:  1977       Impact factor: 3.688
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  79 in total

1.  Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.

Authors:  X Chen; K Kinoshita; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

2.  Sp1 binds to the precise locus of end processing within the terminal repeats of Epstein-Barr virus DNA.

Authors:  R Sun; T A Spain; S F Lin; G Miller
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

3.  Detection of gene targeting by co-conversion of a single nucleotide change during replacement recombination at the immunoglobulin mu heavy chain locus.

Authors:  A J Smith; B Kalogerakis
Journal:  Nucleic Acids Res       Date:  1991-12       Impact factor: 16.971

Review 4.  Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

Authors:  P Vogt
Journal:  Hum Genet       Date:  1990-03       Impact factor: 4.132

5.  Antigen dose-dependent predominance of either direct or sequential switch in IgE antibody responses.

Authors:  S Sudowe; A Rademaekers; E Kölsch
Journal:  Immunology       Date:  1997-07       Impact factor: 7.397

6.  Unique sequences are interspersed among tandemly repeated elements in the murine gamma 1 switch segment.

Authors:  M Mowatt; C Dery; W Dunnick
Journal:  Nucleic Acids Res       Date:  1985-01-11       Impact factor: 16.971

7.  Molecular characterization of novel reciprocal translocation t(6;14) in an Epstein-Barr virus-transformed B cell precursor.

Authors:  M Otsu; S Katamine; M Uno; M Yamaki; Y Ono; G Klein; M S Sasaki; Y Yaoita; T Honjo
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

8.  DNA sequence associated with chromosome translocations in mouse plasmacytomas.

Authors:  L J Harris; P D'Eustachio; F H Ruddle; K B Marcu
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

9.  Genome complexity in the coelacanth is reflected in its adaptive immune system.

Authors:  Nil Ratan Saha; Tatsuya Ota; Gary W Litman; John Hansen; Zuly Parra; Ellen Hsu; Francesco Buonocore; Adriana Canapa; Jan-Fang Cheng; Chris T Amemiya
Journal:  J Exp Zool B Mol Dev Evol       Date:  2014-01-24       Impact factor: 2.656

10.  Nonhomologous recombination at sites within the mouse JH-C delta locus accompanies C mu deletion and switch to immunoglobulin D secretion.

Authors:  J D Owens; F D Finkelman; J D Mountz; J F Mushinski
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272
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