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Literature DB >> 6766935

Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine.

Abstract

Chloroquine was found to prevent the cytotoxic action of diphtheria toxin on cultured monkey kidney cells. Analysis of the cellular processing of 125I-labeled diphtheria toxin showed that chloroquine does not affect the rate or extent of toxin uptake but substantially blocks degradation. These studies provide strong evidence that diphtheria toxin enters monkey kidney cells primarily by adsorptive endocytosis and suggest that lysosomal processing is involved in intracellular activation of the proenzyme form of the toxin.

Entities: Chemical

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Year: 1980 PMID： 6766935

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

29 in total

1. Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

Authors: J R Murphy; W Bishai; M Borowski; A Miyanohara; J Boyd; S Nagle
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

2. Structure-function analyses of diphtheria toxin by use of monoclonal antibodies.

Authors: J M Rolf; L Eidels
Journal: Infect Immun Date: 1993-03 Impact factor: 3.441

3. Interaction of tetanus toxin with lipid vesicles. Effects of pH, surface charge, and transmembrane potential on the kinetics of channel formation.

Authors: G Menestrina; S Forti; F Gambale
Journal: Biophys J Date: 1989-03 Impact factor: 4.033

4. Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.

Authors: D H Hoch; M Romero-Mira; B E Ehrlich; A Finkelstein; B R DasGupta; L L Simpson
Journal: Proc Natl Acad Sci U S A Date: 1985-03 Impact factor: 11.205

5. Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle.

Authors: L J Sturzenbecker; M Nibert; D Furlong; B N Fields
Journal: J Virol Date: 1987-08 Impact factor: 5.103

6. Pertussis toxin-catalyzed ADP-ribosylation of Gi-2 and Gi-3 in CHO cells is modulated by inhibitors of intracellular trafficking.

Authors: Y Xu; J T Barbieri
Journal: Infect Immun Date: 1996-02 Impact factor: 3.441

Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine.

1. Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

2. Structure-function analyses of diphtheria toxin by use of monoclonal antibodies.

3. Interaction of tetanus toxin with lipid vesicles. Effects of pH, surface charge, and transmembrane potential on the kinetics of channel formation.

4. Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.

5. Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle.

6. Pertussis toxin-catalyzed ADP-ribosylation of Gi-2 and Gi-3 in CHO cells is modulated by inhibitors of intracellular trafficking.

7. Rapid cellular removal of a membrane-inserted foreign polypeptide.

Review 8. Transglutaminase and receptor-mediated endocytosis in macrophages and cultured fibroblasts.

9. Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes.

10. Monensin blocks the transport of diphtheria toxin to the cell cytoplasm.