Literature DB >> 2885424

Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle.

L J Sturzenbecker, M Nibert, D Furlong, B N Fields.   

Abstract

Lysosomotropic drugs such as NH4Cl have been useful for studying the role of low pH in early events in virus infection. NH4Cl blocks the production of infectious progeny virus in mammalian reovirus-infected cells. The inhibitory effect of NH4Cl is mediated by an inhibition of intracellular digestion of reovirus outer capsid proteins. In vitro digestion of viral outer capsid proteins produces infectious partially uncoated particles, called intermediate subviral particles, which are no longer inhibited by the presence of NH4Cl. These results indicate that proteolytic processing of reovirus outer capsid proteins takes place in a low pH compartment of the cell and is an essential step in the viral infectious cycle.

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Year:  1987        PMID： 2885424      PMCID： PMC255643     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  46 in total

1.  Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide.

Authors:  S G Lazarowitz; P W Choppin
Journal:  Virology       Date:  1975-12       Impact factor: 3.616

2.  Activation of influenza A viruses by trypsin treatment.

Authors:  H D Klenk; R Rott; M Orlich; J Blödorn
Journal:  Virology       Date:  1975-12       Impact factor: 3.616

3.  Infectious reovirus subviral particles: virus replication, cellular cytopathology, and DNA synthesis.

Authors:  D C Cox; W Clinkscales
Journal:  Virology       Date:  1976-10-01       Impact factor: 3.616

Review 4.  Commentary. Lysosomotropic agents.

Authors:  C de Duve; T de Barsy; B Poole; A Trouet; P Tulkens; F Van Hoof
Journal:  Biochem Pharmacol       Date:  1974-09-15       Impact factor: 5.858

5.  Identification of biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity of proteolytic cleavage of an inactive precursor protein of Sendai virus.

Authors:  A Scheid; P W Choppin
Journal:  Virology       Date:  1974-02       Impact factor: 3.616

6.  Trypsin action on the growth of Sendai virus in tissue culture cells. 3. Structural difference of Sendai viruses grown in eggs and tissue culture cells.

Authors:  M Homma; M Ouchi
Journal:  J Virol       Date:  1973-12       Impact factor: 5.103

7.  Reovirus transcriptase activation in vitro: involvement of an endogenous uncoating activity in the second stage of the process.

Authors:  J Borsa; D G Long; M D Sargent; T P Copps; J D Chapman
Journal:  Intervirology       Date:  1974       Impact factor: 1.763

8.  Studies on the effect of chymotrypsin on reovirions.

Authors:  W K Joklik
Journal:  Virology       Date:  1972-09       Impact factor: 3.616

9.  Diphtheria toxin entry into cells is facilitated by low pH.

Authors:  K Sandvig; S Olsnes
Journal:  J Cell Biol       Date:  1980-12       Impact factor: 10.539

10.  Receptor-mediated internalization of Pseudomonas toxin by mouse fibroblasts.

Authors:  D FitzGerald; R E Morris; C B Saelinger
Journal:  Cell       Date:  1980-10       Impact factor: 66.850
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  153 in total

1.  Structure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.

Authors:  A M Olland; J Jané-Valbuena; L A Schiff; M L Nibert; S C Harrison
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

2.  Thermostability of reovirus disassembly intermediates (ISVPs) correlates with genetic, biochemical, and thermodynamic properties of major surface protein mu1.

Authors:  Jason K Middleton; Tonya F Severson; Kartik Chandran; Anne Lynn Gillian; John Yin; Max L Nibert
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

3.  Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein.

Authors:  K Chandran; X Zhang; N H Olson; S B Walker; J D Chappell; T S Dermody; T S Baker; M L Nibert
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

4.  Sites and determinants of early cleavages in the proteolytic processing pathway of reovirus surface protein sigma3.

Authors:  Judit Jané-Valbuena; Laura A Breun; Leslie A Schiff; Max L Nibert
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

5.  The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry.

Authors:  Kartik Chandran; John S L Parker; Marcelo Ehrlich; Tomas Kirchhausen; Max L Nibert
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

6.  Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A.

Authors:  Xing Zhang; Stephen B Walker; Paul R Chipman; Max L Nibert; Timothy S Baker
Journal:  Nat Struct Biol       Date:  2003-11-09

7.  A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure.

Authors:  Gregory J Wilson; Emma L Nason; Charles S Hardy; Daniel H Ebert; J Denise Wetzel; B V Venkataram Prasad; Terence S Dermody
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

8.  Putative autocleavage of outer capsid protein micro1, allowing release of myristoylated peptide micro1N during particle uncoating, is critical for cell entry by reovirus.

Authors:  Amy L Odegard; Kartik Chandran; Xing Zhang; John S L Parker; Timothy S Baker; Max L Nibert
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

9.  Proteolytic cleavage of the reovirus sigma 3 protein results in enhanced double-stranded RNA-binding activity: identification of a repeated basic amino acid motif within the C-terminal binding region.

Authors:  J E Miller; C E Samuel
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

10.  Identification of functional domains in reovirus replication proteins muNS and mu2.

Authors:  Takeshi Kobayashi; Laura S Ooms; James D Chappell; Terence S Dermody
Journal:  J Virol       Date:  2009-01-28       Impact factor: 5.103
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