Literature DB >> 6766206

The role of gene deletion in the immunoglobulin heavy chain switch.

T H Rabbitts, A Forster, W Dunnick, D L Bentley.   

Abstract

We have examined the arrangement of the genes for the mouse heavy chain subclasses gamma 2b, gamma 2a and gamma 1 by the Southern hybridisation procedure. Evidence has been found for rearrangement involving the gamma 2b and gamma 2a CH genes in the DNA of cells making IgG2b and IgG2a respectively. The DNA of an IgG2b-secreting line lacks detectable C gamma 1 gene, whilst the DNA of an IgG2a-secreting line lacks detectable C gamma 1 and C gamma 2b genes. The DNA of a cell line secreting IgA lacks detectable C gamma genes. These observations implicate deletion in the mechanism of the H-chain switch and allow a preliminary ordering of some of the CH genes in the mouse genome.

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Year:  1980        PMID： 6766206     DOI： 10.1038/283351a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  44 in total

1.  Copy choice mechanism of immunoglobulin heavy-chain switch recombination.

Authors:  W Dunnick; J Stavnezer
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

2.  Unique sequences are interspersed among tandemly repeated elements in the murine gamma 1 switch segment.

Authors:  M Mowatt; C Dery; W Dunnick
Journal:  Nucleic Acids Res       Date:  1985-01-11       Impact factor: 16.971

3.  Construction of recombinant plasmids containing Xenopus immunoglobulin heavy chain DNA sequences.

Authors:  R D Brown; R W Armentrout; M D Cochran; J Cappello; S O Langemeier
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

4.  Three monoclonal immunoglobulins, an IgG2(kappa), an IgM(kappa) and an IgM/A hybrid, in one patient. II. Sharing of common variable regions.

Authors:  T K Kuan; E Tung; I Y Wang; A C Wang
Journal:  Immunology       Date:  1981-10       Impact factor: 7.397

5.  Linkage of the four gamma subclass heavy chain genes.

Authors:  W Roeder; R Maki; A Traunecker; S Tonegawa
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

6.  A switch region inversion contributes to the aberrant rearrangement of a mu immunoglobulin heavy chain gene in MPC-11 cells.

Authors:  R Greenberg; R B Lang; M S Diamond; K B Marcu
Journal:  Nucleic Acids Res       Date:  1982-12-11       Impact factor: 16.971

7.  DNA sequence associated with chromosome translocations in mouse plasmacytomas.

Authors:  L J Harris; P D'Eustachio; F H Ruddle; K B Marcu
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

8.  Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.

Authors:  U Storb; B Arp; R Wilson
Journal:  Nucleic Acids Res       Date:  1980-10-24       Impact factor: 16.971

9.  Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes.

Authors:  T Kawakami; N Takahashi; T Honjo
Journal:  Nucleic Acids Res       Date:  1980-09-11       Impact factor: 16.971

10.  Cloned embryonic DNA sequences flanking the mouse immunoglobulin C gamma 3 and C gamma 1 genes.

Authors:  J M Adams; E Webb; S Gerondakis; S Cory
Journal:  Nucleic Acids Res       Date:  1980-12-20       Impact factor: 16.971
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