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Literature DB >> 6264445

Linkage of the four gamma subclass heavy chain genes.

W Roeder, R Maki, A Traunecker, S Tonegawa.

Abstract

The genes for the heavy-chain constant regions of the four gamma subclass immunoglobulins were identified in a set of overlapping mouse DNA fragments representing about 100 kilobase pairs (kb) of the mouse genome that was cloned from bacteriophage lambda libraries of BALB/c mouse embryo DNA. R-loop mapping studies show that the genes are located 5'-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-3' and lie in the same transcriptional orientation. Two DNA segments, one of 19 kb and another of 15 kb, that surround the C gamma 2b and C gamma 2a genes, respectively, show considerable homology and implicate a tandem duplication mechanism in the evolution of this gene cluster.

Entities: Gene Species

Mesh：

Substances：

Year: 1981 PMID： 6264445 PMCID： PMC319076 DOI： 10.1073/pnas.78.1.474

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

33 in total

1. Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors: W D Benton; R W Davis
Journal: Science Date: 1977-04-08 Impact factor: 47.728

2. Cloning of an immunoglobulin variable region gene from mouse embryo.

Authors: S Tonegawa; C Brack; N Hozumi; R Schuller
Journal: Proc Natl Acad Sci U S A Date: 1977-08 Impact factor: 11.205

3. Charon phages: safer derivatives of bacteriophage lambda for DNA cloning.

Authors: F R Blattner; B G Williams; A E Blechl; K Denniston-Thompson; H E Faber; L Furlong; D J Grunwald; D O Kiefer; D D Moore; J W Schumm; E L Sheldon; O Smithies
Journal: Science Date: 1977-04-08 Impact factor: 47.728

4. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

Authors: N Hozumi; S Tonegawa
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205

5. Studies of generation of B-cell diversity in mouse, man, and chicken.

Authors: M D Cooper; J F Kearney; P M Lydyard; C E Grossi; A R Lawton
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

6. Synthesis of multiple immunoglobulin classes by single lymphocytes.

Authors: B Pernis; L Forni; A L Luzzati
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

7. Immunoglobulins as cell receptors.

Authors: B Pernis; L Forni; L Amante
Journal: Ann N Y Acad Sci Date: 1971-12-31 Impact factor: 5.691

8. Organization of immunoglobulin heavy chain genes and allelic deletion model.

Authors: T Honjo; T Kataoka
Journal: Proc Natl Acad Sci U S A Date: 1978-05 Impact factor: 11.205

9. Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.

Authors: K Adetugbo
Journal: J Biol Chem Date: 1978-09-10 Impact factor: 5.157

10. Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA.

Authors: J L Sikorav; C Auffray; F Rougeon
Journal: Nucleic Acids Res Date: 1980-07-25 Impact factor: 16.971

15 in total

1. Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.

Authors: E H Brown; M A Iqbal; S Stuart; K S Hatton; J Valinsky; C L Schildkraut
Journal: Mol Cell Biol Date: 1987-01 Impact factor: 4.272

2. Sigma region located between C mu and C delta genes of human immunoglobulin heavy chain: possible involvement of tRNA-like structure in RNA splicing.

Authors: Y Akahori; H Handa; K Imai; M Abe; K Kameyama; M Hibiya; H Yasui; K Okamura; M Naito; H Matsuoka
Journal: Nucleic Acids Res Date: 1988-10-25 Impact factor: 16.971

3. Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin.

Authors: H Hisajima; Y Nishida; S Nakai; N Takahashi; S Ueda; T Honjo
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

4. Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.

Authors: C Wood; S Tonegawa
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205