Literature DB >> 6723928

Blood and tissue distribution of cyclosporin A after a single oral dose in the rat.

K Nooter, B Meershoek, W Spaans, P Sonneveld, R Oostrum, J Deurloo.   

Abstract

After a single oral dose of cyclosporin A (82 mg/kg) in rats, tissue (kidneys liver and brain) and blood levels reached maximum values (approximately 80 micrograms/g and 3.5 micrograms/ml) between 3 and 7 h after drug administration. Drug elimination continued for at least 5 days. The 24-h urine and bile elimination was 2% for each.

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Year:  1984        PMID: 6723928     DOI: 10.1007/BF01982329

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  12 in total

1.  Cyclosporin A: an immunosuppressive agent preferentially active against proliferating T cells.

Authors:  D J White; A M Plumb; G Pawelec; G Brons
Journal:  Transplantation       Date:  1979-01       Impact factor: 4.939

2.  Cyclosporin A tissue levels in a cadaveric renal allograft recipient.

Authors:  B D Kahan; C T Van Buren; M Boileau; M Ried; W D Payne; S Flechner; J Newburger
Journal:  Transplantation       Date:  1983-01       Impact factor: 4.939

3.  Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

Authors:  J F Borel; C Feurer; C Magnée; H Stähelin
Journal:  Immunology       Date:  1977-06       Impact factor: 7.397

4.  Nephrotoxicity of cyclosporin A in liver and kidney transplant patients.

Authors:  G B Klintmalm; S Iwatsuki; T E Starzl
Journal:  Lancet       Date:  1981-02-28       Impact factor: 79.321

5.  A radioimmunoassay to measure cyclosporin A in plasma and serum samples.

Authors:  P Donatsch; E Abisch; M Homberger; R Traber; M Trapp; R Voges
Journal:  J Immunoassay       Date:  1981

6.  Cyclosporin-A to prevent graft-versus-host disease: a pilot study in 22 patients receiving allogeneic marrow transplants.

Authors:  P J Tutschka; W E Beschorner; A D Hess; G W Santos
Journal:  Blood       Date:  1983-02       Impact factor: 22.113

7.  Nephrotoxicity in bone marrow transplant recipients treated with cyclosporin A.

Authors:  J M Hows; P M Chipping; S Fairhead; J Smith; A Baughan; E C Gordon-Smith
Journal:  Br J Haematol       Date:  1983-05       Impact factor: 6.998

8.  Acute renal toxicity with combined use of amphotericin B and cyclosporine after marrow transplantation.

Authors:  M S Kennedy; H J Deeg; M Siegel; J J Crowley; R Storb; E D Thomas
Journal:  Transplantation       Date:  1983-03       Impact factor: 4.939

9.  Cyclosporin A to prevent graft-versus-host disease in man after allogeneic bone-marrow transplantation.

Authors:  R L Powles; H M Clink; D Spence; G Morgenstern; J G Watson; P J Selby; M Woods; A Barrett; B Jameson; J Sloane; S D Lawler; H E Kay; D Lawson; T J McElwain; P Alexander
Journal:  Lancet       Date:  1980-02-16       Impact factor: 79.321

10.  Nephrotoxicity of cyclosporin A after allogeneic marrow transplantation: glomerular thromboses and tubular injury.

Authors:  H Shulman; G Striker; H J Deeg; M Kennedy; R Storb; E D Thomas
Journal:  N Engl J Med       Date:  1981-12-03       Impact factor: 91.245

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