Literature DB >> 7287910

A radioimmunoassay to measure cyclosporin A in plasma and serum samples.

P Donatsch, E Abisch, M Homberger, R Traber, M Trapp, R Voges.   

Abstract

A radioimmunoassay for the immunosuppressant drug Cyclosporin A has been developed which makes possible the monitoring of the drug by direct measurements in clinical plasma and serum samples. The antisera have been produced in rabbits using the hemisuccinate derivative of a structural analogue of Cyclosporin A as a hapten. The assay has both adequate specificity and sensitivity for Cyclosporin A to be suitable for the routine monitoring of therapy. Some degree of cross-reactivity has been shown to occur with four metabolites which were isolated from urine samples.

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Year:  1981        PMID： 7287910     DOI： 10.1080/01971528108062989

Source DB:  PubMed          Journal:  J Immunoassay        ISSN： 0197-1522


  55 in total

1.  Pharmacokinetics and chronic toxicity of cyclosporine A in genetic hydroxylation-deficient dark Agouti rats.

Authors:  S Koehn; F J Frey; R F Speck; T Zeugin; T Schaffner; A Zimmermann; B M Frey
Journal:  J Pharmacokinet Biopharm       Date:  1990-10

2.  Treatment of chronic relapsing inflammatory demyelinating polyneuropathy by cyclosporin A and plasma exchange. A case report.

Authors:  H Hefter; K B Sprenger; G Arendt; D Hafner
Journal:  J Neurol       Date:  1990-08       Impact factor: 4.849

3.  Prediction of acute graft rejection in renal transplantation: the utility of cyclosporine blood concentrations.

Authors:  J Grevel; K L Napoli; M S Welsh; N E Atkinson; B D Kahan
Journal:  Pharm Res       Date:  1991-02       Impact factor: 4.200

4.  Biliary Excretion of Cyclosporine in Liver Transplant Patients.

Authors:  R Venkataramanan; T E Starzl; S Yang; G J Burckart; R J Ptachcinski; B W Shaw; S Iwatsuki; D H Van Thiel; A Sanghvi; H Seltman
Journal:  Transplant Proc       Date:  1985-02       Impact factor: 1.066

5.  Prolonged survival of allogeneic corneal grafts in rabbits treated with topically applied cyclosporin A: systemic absorption and local immunosuppressive effect.

Authors:  B Foets; L Missotten; P Vanderveeren; W Goossens
Journal:  Br J Ophthalmol       Date:  1985-08       Impact factor: 4.638

6.  Clinical pharmacokinetics of ciclosporin A in bone marrow transplantation patients.

Authors:  P Bertault-Pérès; D Maraninchi; Y Carcassonne; J P Cano; J Barbet
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

7.  Distribution and concentration of cyclosporin in human blood.

Authors:  K Atkinson; K Britton; J Biggs
Journal:  J Clin Pathol       Date:  1984-10       Impact factor: 3.411

8.  Experience with cyclosporine and steroids in clinical renal transplantation.

Authors:  N L Tilney; E L Milford; J L Araujo; T B Strom; C B Carpenter; R L Kirkman
Journal:  Ann Surg       Date:  1984-11       Impact factor: 12.969

9.  Cyclosporine trough concentration monitoring in liver transplant patients.

Authors:  G J Burckart; R J Ptachcinski; R Venkataramanan; S Iwatsuki; C Esquivel; D H Van Thiel; T E Starzl
Journal:  Transplant Proc       Date:  1986-12       Impact factor: 1.066

10.  Cyclosporin treatment for rheumatoid arthritis: a placebo controlled, double blind, multicentre study.

Authors:  A W van Rijthoven; B A Dijkmans; H S Goei The; J Hermans; Z L Montnor-Beckers; P C Jacobs; A Cats
Journal:  Ann Rheum Dis       Date:  1986-09       Impact factor: 19.103
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