Literature DB >> 6722977

Induction of sarcomas in rats by subcutaneous injection of dinitropyrenes.

H Ohgaki, C Negishi, K Wakabayashi, K Kusama, S Sato, T Sugimura.   

Abstract

The carcinogenicities of potent mutagenic dinitropyrenes were examined by their subcutaneous injections into male F344/ DuCrj rats. Animals were injected with 0.2 mg each of 1,3- and 1,8-dinitropyrenes (1,3- and 1,8- DNPs ) dissolved in 0.2 ml of dimethyl sulfoxide (DMSO) twice a week for 10 weeks. In rats treated with 1,8-DNP, sarcomas were induced at the sites of injection in all 10 animals tested between the 113th and 127th experimental days. In rats treated with 1,3-DNP, 10 of 10 rats developed sarcomas between days 119 and 320. Some tumors induced by these chemicals were transplantable into the same strain of rats. No tumors developed in control rats, which received only DMSO.

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Year:  1984        PMID： 6722977     DOI： 10.1093/carcin/5.5.583

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  6 in total

1.  Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.

Authors:  T Tahira; K Hayashi; M Ochiai; N Tsuchida; M Nagao; T Sugimura
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

2.  The nature of the mutagenicity and carcinogenicity of nitrated, aromatic compounds in the environment.

Authors:  H Tokiwa; R Nakagawa; K Horikawa; A Ohkubo
Journal:  Environ Health Perspect       Date:  1987-08       Impact factor: 9.031

Review 3.  Past, present, and future of mutagens in cooked foods.

Authors:  T Sugimura
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

4.  Contribution of organic particulates to respiratory cancer.

Authors:  G Matanoski; L Fishbein; C Redmond; H Rosenkranz; L Wallace
Journal:  Environ Health Perspect       Date:  1986-12       Impact factor: 9.031

5.  Mutagenic activities of heterocyclic amines in Chinese hamster lung cells in culture.

Authors:  M Terada; M Nagao; M Nakayasu; H Sakamoto; F Nakasato; T Sugimura
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

6.  Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene.

Authors:  J A Holme; H E Nyvold; V Tat; V M Arlt; A Bhargava; K B Gutzkow; A Solhaug; M Låg; R Becher; P E Schwarze; K Ask; L Ekeren; J Øvrevik
Journal:  Toxicol Rep       Date:  2014-07-27
  6 in total

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