| Literature DB >> 671453 |
G J Hatheway, C Hansch, K H Kim, S R Milstein, C L Schmidt, R N Smith, F R Quinn.
Abstract
Quantitative structure-activity relationships (QSAR) have been formulated for phenyl-, pyrazolyl-, and imidazolyltriazenes acting L1210 leukemia in mice. All three sets of congeners have the same ideal lipophilicity (log Po approximately 1). Electron releasing substituents increase potency; ortho substitution decreases activity. The synthesis of a number of new triazenes and some of their partition coefficients are reported.Entities:
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Year: 1978 PMID： 671453 DOI： 10.1021/jm00204a012
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446