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Literature DB >> 6704286

The efficacy and pharmacokinetics of sodium salicylate in post-operative dental pain.

Abstract

Sodium salicylate, 537 mg and 1074 mg were compared in a double-blind cross-over study in 24 patients with post-operative pain following removal of impacted lower third molars. No significant analgesic effect was observed after either dose of sodium salicylate, either overall or at any time point during the 5 h investigation period. Peak plasma concentrations of salicylate after 537 mg were observed at 30 min after dosage, whereas peak plasma salicylate concentrations after 1074 mg sodium salicylate occurred at 45 min after dosage.

Entities: Chemical Disease Species

Mesh：

Substances：
Sodium Salicylate

Year: 1984 PMID： 6704286 PMCID： PMC1463320 DOI： 10.1111/j.1365-2125.1984.tb02331.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

8 in total

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Authors: J R Vane
Journal: Nat New Biol Date: 1971-06-23

2. Pharmacokinetics of parenteral paracetamol and its analgesic effects in post-operative dental pain.

Authors: R A Seymour; M D Rawlins
Journal: Eur J Clin Pharmacol Date: 1981 Impact factor: 2.953

3. Specific and sensitive method for the determination of aspirin and salicylic acid in plasma using reversed-phase high-performance liquid chromatography.

Authors: L Y Lo; A Bye
Journal: J Chromatogr Date: 1980-03-14

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Authors: G J Roth; P W Majerus
Journal: J Clin Invest Date: 1975-09 Impact factor: 14.808

5. Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

Authors: M I Siegel; R T McConnell; P Cuatrecasas
Journal: Proc Natl Acad Sci U S A Date: 1979-08 Impact factor: 11.205

6. A model to evaluate mild analgesics in oral surgery outpatients.

Authors: S A Cooper; W T Beaver
Journal: Clin Pharmacol Ther Date: 1976-08 Impact factor: 6.875

7. Efficacy and pharmacokinetics of aspirin in post-operative dental pain.

Authors: R A Seymour; M D Rawlins
Journal: Br J Clin Pharmacol Date: 1982-06 Impact factor: 4.335

8. Inhibition of platelet prostaglandin synthetase by oral aspirin.

Authors: J W Burch; N Stanford; P W Majerus
Journal: J Clin Invest Date: 1978-02 Impact factor: 14.808

8 in total

6 in total

The efficacy and pharmacokinetics of sodium salicylate in post-operative dental pain.

1. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

2. Pharmacokinetics of parenteral paracetamol and its analgesic effects in post-operative dental pain.

3. Specific and sensitive method for the determination of aspirin and salicylic acid in plasma using reversed-phase high-performance liquid chromatography.

4. The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

5. Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

6. A model to evaluate mild analgesics in oral surgery outpatients.

7. Efficacy and pharmacokinetics of aspirin in post-operative dental pain.

8. Inhibition of platelet prostaglandin synthetase by oral aspirin.

Review 1. Use of analgesics in postoperative dental pain: a review.

2. The efficacy of benorylate in postoperative dental pain.

Review 3. Clinical significance of esterases in man.

4. Aspirin metabolism and efficacy in postoperative dental pain.

Review 5. Aspirin and related derivatives of salicylic acid.

6. Comparison of controlled-release ketoprofen and diclofenac in the control of post-surgical dental pain.