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Literature DB >> 115007

Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

M I Siegel, R T McConnell, P Cuatrecasas.

Abstract

Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the conversion of 12-hydroperoxy- to 12-hydroxy-5,8,10,14-eicosatetraenoic acid.

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Year: 1979 PMID： 115007 PMCID： PMC383916 DOI： 10.1073/pnas.76.8.3774

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

1. Acute hypotension due to carrageenan, arachidonic acid and slow reacting substance C in the rabbit: role of platelets and nature of pharmacological antagonism.

Authors: B B Vargaftig; J Lefort
Journal: Eur J Pharmacol Date: 1977-05-15 Impact factor: 4.432

2. Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets.

Authors: E G Lapetina; C J Schmitges; K Chandrabose; P Cuatrecases
Journal: Biochem Biophys Res Commun Date: 1977-06-06 Impact factor: 3.575

3. Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products.

Authors: E G Lapetina; K A Chandrabose; P Cuatrecasas
Journal: Proc Natl Acad Sci U S A Date: 1978-02 Impact factor: 11.205

4. Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat.

Authors: B B Vargaftig
Journal: J Pharm Pharmacol Date: 1978-02 Impact factor: 3.765

5. Pharmacokinetics of indomethacin.

Authors: G Alván; M Orme; L Bertilsson; R Ekstrand; L Palmér
Journal: Clin Pharmacol Ther Date: 1975-09 Impact factor: 6.875

6. New aspects of chemotaxis. Specific target-cell attraction by lipid and lipoprotein fractions of Escherichia coli chemotactic factor.

Authors: J A Tainer; S R Turner; W S Lynn
Journal: Am J Pathol Date: 1975-11 Impact factor: 4.307

7. Prostaglandin I2 as a potentiator of acute inflammation in rats.

Authors: K Komoriya; H Ohmori; A Azuma; S Kurozumi; Y Hashimoto; K C Nicolaou; W E Barnette; R L Magolda
Journal: Prostaglandins Date: 1978-04

8. Inhibition of aspirin-induced bronchoconstriction by sodium cromoglycate inhalation.

Authors: N A Martelli; G Usandivaras
Journal: Thorax Date: 1977-12 Impact factor: 9.139

9. Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes.

Authors: J A Salmon; D R Smith; R J Flower; S Moncada; J R Vane
Journal: Biochim Biophys Acta Date: 1978-03-14

10. Inhibition of platelet prostaglandin synthetase by oral aspirin.

Authors: J W Burch; N Stanford; P W Majerus
Journal: J Clin Invest Date: 1978-02 Impact factor: 14.808

35 in total

1. Mechanical stretch reveals different components of endothelial-mediated vascular tone in rat aortic strips.

Authors: S Franchi-Micheli; P Failli; L Mazzetti; D Bani; M Ciuffi; L Zilletti
Journal: Br J Pharmacol Date: 2000-12 Impact factor: 8.739

2. Enhanced protein denaturation in indomethacin-treated cells.

Authors: I Roussou; v T Nguyen; G N Pagoulatos; O Bensaude
Journal: Cell Stress Chaperones Date: 2000-01 Impact factor: 3.667

3. Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade.

Authors: M A Boukili; M Bureau; V Lagente; J Lefort; A Lellouch-Tubiana; E Malanchère; B B Vargaftig
Journal: Br J Pharmacol Date: 1986-10 Impact factor: 8.739

4. Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity. Studies in human neutrophils and liposomes.

Authors: S B Abramson; B Cherksey; D Gude; J Leszczynska-Piziak; M R Philips; L Blau; G Weissmann
Journal: Inflammation Date: 1990-02 Impact factor: 4.092

5. Injury to endothelial cells by phagocytosing polymorphonuclear leukocytes and modulatory role of lipoxygenase products.

Authors: C M Vandenbroucke-Grauls; H M Thijssen; K P van Kessel; B S van Asbeck; J Verhoef
Journal: Infect Immun Date: 1987-06 Impact factor: 3.441

Review 6. Aspirin and colorectal cancer: back to the future.

Authors: David Tougeron; Dan Sha; Sashidhar Manthravadi; Frank A Sinicrope
Journal: Clin Cancer Res Date: 2013-12-10 Impact factor: 12.531

7. Indomethacin inhibits the increased airway responsiveness to histamine following inhalation of C5a des Arg in rabbits.

Authors: N Berend; C L Armour; J L Black
Journal: Agents Actions Date: 1986-08