Literature DB >> 2563688

The efficacy of benorylate in postoperative dental pain.

U Moore1, R A Seymour, F M Williams, E Nicholson, M D Rawlins.   

Abstract

The efficacy of a single pre-operative dose of benorylate (4 g) was determined in a double-blind, randomized, placebo-controlled parallel study in patients undergoing removal of a single impacted lower third molar. Patients treated with benorylate 4 g reported significantly less pain between 3-6 h after dosage than those treated with placebo. Overall pain scores at 6 h were significantly less in the benorylate group than the placebo group. However, overall pain scores at 12 h did not differ significantly between treatment groups. It is concluded from this study that a single dose of benorylate 4 g given immediately prior to the removal of an impacted lower third molar provides limited pain control during the postoperative period.

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Year:  1989        PMID: 2563688     DOI: 10.1007/BF00561020

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN: 0031-6970            Impact factor:   2.953


  13 in total

1.  Comparison of benorylate and indomethacin in the symptomatic control of arthritic disorders.

Authors:  M H Coigley
Journal:  Practitioner       Date:  1975-09

2.  Comparison of aspirin and benorylate in the treatment of rheumatoid arthritis.

Authors:  D L Beales; H C Burry; R Grahame
Journal:  Br Med J       Date:  1972-05-27

3.  [Comparative study of 2-acetoxy-4-acetaminophenyl benzoate (Win 11,450), aspirin, and placebo in stomatology].

Authors:  C Vialatel; R Gaillon
Journal:  Therapie       Date:  1968 May-Jun       Impact factor: 2.070

4.  Clinical consequences of complaints and complications after removal of the mandibular third molar.

Authors:  A V van Gool; J J Ten Bosch; G Boering
Journal:  Int J Oral Surg       Date:  1977-02

5.  Analgesic methodology: a brief history and commentary.

Authors:  L Lasagna
Journal:  J Clin Pharmacol       Date:  1980 May-Jun       Impact factor: 3.126

6.  The efficacy and pharmacokinetics of sodium salicylate in post-operative dental pain.

Authors:  R A Seymour; M D Rawlins; A Clothier
Journal:  Br J Clin Pharmacol       Date:  1984-02       Impact factor: 4.335

7.  Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen.

Authors:  P Lökken; I Olsen; I Bruaset; K Norman-Pedersen
Journal:  Eur J Clin Pharmacol       Date:  1975-04-04       Impact factor: 2.953

8.  A model to evaluate mild analgesics in oral surgery outpatients.

Authors:  S A Cooper; W T Beaver
Journal:  Clin Pharmacol Ther       Date:  1976-08       Impact factor: 6.875

9.  An investigation into post-operative pain after third molar surgery under local analgesia.

Authors:  R A Seymour; J G Meechan; G S Blair
Journal:  Br J Oral Maxillofac Surg       Date:  1985-12       Impact factor: 1.651

10.  Suppression of postoperative pain by preoperative administration of ibuprofen in comparison to placebo, acetaminophen, and acetaminophen plus codeine.

Authors:  R A Dionne; R A Campbell; S A Cooper; D L Hall; B Buckingham
Journal:  J Clin Pharmacol       Date:  1983-01       Impact factor: 3.126

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  1 in total

1.  Benorylate hydrolysis by human plasma and human liver.

Authors:  F M Williams; U Moore; R A Seymour; E M Mutch; E Nicholson; P Wright; H Wynne; P G Blain; M D Rawlins
Journal:  Br J Clin Pharmacol       Date:  1989-12       Impact factor: 4.335

  1 in total

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