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Literature DB >> 6703678

Concentrations of vancomycin in bone and serum of normal rabbits and those with osteomyelitis.

Abstract

The concentrations of vancomycin in the bone and serum of rabbits with Staphylococcus aureus osteomyelitis were assessed after each rabbit was given a single dose of vancomycin. Simultaneous mean concentrations of vancomycin in infected rabbits 1 h after administration of the antibiotic were 36.4 +/- 4.6 micrograms/ml (serum), 5.3 +/- 0.8 microgram/g (infected bone), and 3.0 +/- 0.2 micrograms/g (noninfected bone). Concentrations of vancomycin in serum of normal controls were higher than concentrations of vancomycin in serum of osteomyelitic rabbits after 1, 2, 3, and 6 h.

Entities: Chemical Disease Species

Mesh：

Substances：
Vancomycin

Year: 1984 PMID： 6703678 PMCID： PMC185454 DOI： 10.1128/AAC.25.1.140

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

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Journal: Antimicrob Agents Chemother Date: 1978-01 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1982-09 Impact factor: 5.191

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Journal: J Infect Dis Date: 1983-02 Impact factor: 5.226

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Journal: Mayo Clin Proc Date: 1983-02 Impact factor: 7.616

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Journal: J Clin Pharmacol Date: 1980-04 Impact factor: 3.126

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Authors: R Fekety
Journal: Med Clin North Am Date: 1982-01 Impact factor: 5.456

6 in total

1. Penetration of vancomycin in uninfected sternal bone.

Authors: L Massias; C Dubois; P de Lentdecker; O Brodaty; M Fischler; R Farinotti
Journal: Antimicrob Agents Chemother Date: 1992-11 Impact factor: 5.191

2. Effect of delayed pulsed-wave ultrasound on local pharmacokinetics and pharmacodynamics of vancomycin-loaded acrylic bone cement in vivo.

Authors: Xun-Zi Cai; Shi-Gui Yan; Hao-Bo Wu; Rong-Xin He; Xue-Song Dai; Hai-Xiang Chen; Rui-Jian Yan; Xin-Hua Zhao
Journal: Antimicrob Agents Chemother Date: 2007-07-09 Impact factor: 5.191

6. Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus.

Authors: Li-Yan Yin; Jason H Calhoun; Jacob K Thomas; Stuart Shapiro; Anne Schmitt-Hoffmann
Journal: Antimicrob Agents Chemother Date: 2008-03-10 Impact factor: 5.191