Literature DB >> 6684395

Determinants of variation in plasma alkaline phosphatase activity: a twin study.

J B Whitfield, N G Martin.   

Abstract

Plasma alkaline phosphatase activity has been measured in 204 pairs of twins aged 18-34. Estimated genetic variance was the same in men and women, after exclusion of the youngest men, but environmental variance was greater in men so that the heritability was .90 +/- .02 in the women and .71 +/- .05 in the 19-34-year-old men. About 15% of the genetic variance was associated with the ABO blood group polymorphism, which is known to affect intestinal alkaline phosphatase. Differences in plasma alkaline phosphatase activity between normal people may be mainly due to genetically determined proportions of isoenzymes of differing stability.

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Year:  1983        PMID： 6684395      PMCID： PMC1685834     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  13 in total

1.  Activities of bone and liver alkaline phosphatases in serum in health and disease.

Authors:  K B Whitaker; L G Whitby; D W Moss
Journal:  Clin Chim Acta       Date:  1977-10-01       Impact factor: 3.786

Review 2.  Model-fitting approaches to the analysis of human behaviour.

Authors:  L J Eaves; K A Last; P A Young; N G Martin
Journal:  Heredity (Edinb)       Date:  1978-12       Impact factor: 3.821

3.  Serum alkaline phosphatase: total activity and isoenzyme determinations made by use of the centrifugal fast analyzer.

Authors:  B E Statland; H H Nishi; D S Young
Journal:  Clin Chem       Date:  1972-12       Impact factor: 8.327

4.  An automated p-nitrophenylphosphate serum alkaline phosphatase procedure for the AutoAnalyzer.

Authors:  S Morgenstern; G Kessler; J Auerbach; R V Flor; B Klein
Journal:  Clin Chem       Date:  1965-09       Impact factor: 8.327

5.  Genetic variability of clinical chemical values.

Authors:  R Havlik; R Garrison; R Fabsitz; M Feinleib
Journal:  Clin Chem       Date:  1977       Impact factor: 8.327

6.  Sex differences in the inheritance of some anthropometric characters in twins.

Authors:  P Clarke; R Jardine; N G Martin; A E Stark; R J Walsh
Journal:  Acta Genet Med Gemellol (Roma)       Date:  1980

7.  Variance components of serum constituents in healthy individuals.

Authors:  A C Van Steirteghem; E A Robertson; D S Young
Journal:  Clin Chem       Date:  1978-02       Impact factor: 8.327

8.  Three serum enzymes in twins.

Authors:  D Hosenfeld; E Drössler
Journal:  Acta Genet Med Gemellol (Roma)       Date:  1970 Jan-Apr

9.  Individual character of variation in time-series studies of healthy people: II. Differences in values for clinical chemical analytes in serum among demographic groups, by age and sex.

Authors:  G Z Williams; G M Widdowson; J Penton
Journal:  Clin Chem       Date:  1978-02       Impact factor: 8.327

10.  Intestinal alkaline phosphatase and the ABO blood group system--a new aspect.

Authors:  P M Bayer; H Hotschek; E Knoth
Journal:  Clin Chim Acta       Date:  1980-11-20       Impact factor: 3.786
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  4 in total

1.  Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density.

Authors:  Carrie M Nielson; Joseph M Zmuda; Amy S Carlos; Wendy J Wagoner; Emily A Larson; Eric S Orwoll; Robert F Klein
Journal:  J Bone Miner Res       Date:  2012-01       Impact factor: 6.741

2.  Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

Authors:  Xin Yuan; Dawn Waterworth; John R B Perry; Noha Lim; Kijoung Song; John C Chambers; Weihua Zhang; Peter Vollenweider; Heide Stirnadel; Toby Johnson; Sven Bergmann; Noam D Beckmann; Yun Li; Luigi Ferrucci; David Melzer; Dena Hernandez; Andrew Singleton; James Scott; Paul Elliott; Gerard Waeber; Lon Cardon; Timothy M Frayling; Jaspal S Kooner; Vincent Mooser
Journal:  Am J Hum Genet       Date:  2008-10       Impact factor: 11.025

3.  A genome-wide association study on liver enzymes in Korean population.

Authors:  Ji Yeon Seo; Jong-Eun Lee; Goh Eun Chung; Eunsoon Shin; Min-Sun Kwak; Jong In Yang; Jeong Yoon Yim
Journal:  PLoS One       Date:  2020-02-21       Impact factor: 3.240

4.  Genotype-Phenotype Associations in 72 Adults with Suspected ALPL-Associated Hypophosphatasia.

Authors:  Nico Maximilian Jandl; Tobias Schmidt; Tim Rolvien; Julian Stürznickel; Konstantin Chrysostomou; Emil von Vopelius; Alexander E Volk; Thorsten Schinke; Christian Kubisch; Michael Amling; Florian Barvencik
Journal:  Calcif Tissue Int       Date:  2020-11-15       Impact factor: 4.333
  4 in total

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