Literature DB >> 6678308

Interferon effects on multiplication, cytoplasmic protein and GFAP content, and morphology in human glioma cells.

K Korosue, I Takeshita, H Mannoji, M Fukui.   

Abstract

Beta-type human fibroblast interferon inhibited the multiplication of human glioma cells in a dose-dependent manner. The inhibitory effects were thought to be due to suppression of the cells entering the S-phase. After interferon treatment with 5 X 10(3) IU/ml for ten days, the mean cell volume, the soluble protein, and the glial fibrillary acidic protein increased to 970%, 190%, and 380% that of the controls, respectively. The interferon-treated cells changed shape and resembled mature astrocytes. It is presumed that beta-type human fibroblast interferon inhibits DNA synthesis of cultured glial cells and subsequently induces specific differentiated proteins and morphologic alteration.

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Year:  1983        PMID： 6678308     DOI： 10.1007/bf00153644

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  26 in total

1.  STUDIES ON SYNCHRONOUS DIVISION OF TISSUE CULTURE CELLS INITIATED BY EXCESS THYMIDINE.

Authors:  D BOOTSMA; L BUDKE; O VOS
Journal:  Exp Cell Res       Date:  1964-01       Impact factor: 3.905

2.  Effects of interferon on the human clonal cell line, RSa: inhibition of macromolecular synthesis.

Authors:  A Fuse; T Kuwata
Journal:  J Gen Virol       Date:  1976-10       Impact factor: 3.891

3.  Interferon inhibition of DNA synthesis and cell division.

Authors:  M V O'Shaughnessy; S H Lee; K R Rozee
Journal:  Can J Microbiol       Date:  1972-02       Impact factor: 2.419

4.  Interferon effects on the growth and division of human fibroblasts.

Authors:  L M Pfeffer; J S Murphy; I Tamm
Journal:  Exp Cell Res       Date:  1979-06       Impact factor: 3.905

5.  Block of glioma cell line in S by interferon.

Authors:  D Lundblad; E Lundgren
Journal:  Int J Cancer       Date:  1981-06-15       Impact factor: 7.396

6.  Glial fibrillary acidic protein from normal and gliosed human brain. Demonstration of multiple related polypeptides.

Authors:  D Dahl; A Bignami
Journal:  Biochim Biophys Acta       Date:  1975-03-28

7.  Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

Authors:  C B Laurell
Journal:  Anal Biochem       Date:  1966-04       Impact factor: 3.365

8.  Determination of glial fibrillary acidic protein (GFAP) in human brain tumors.

Authors:  C M Jacque; C Vinner; M Kujas; M Raoul; J Racadot; N A Baumann
Journal:  J Neurol Sci       Date:  1978-01       Impact factor: 3.181

9.  Thymidine as a synchronizing agent. I. Nucleic acid and protein formation in synchronous HeLa cultures treated with excess thymidine.

Authors:  G P Studzinski; W C Lambert
Journal:  J Cell Physiol       Date:  1969-04       Impact factor: 6.384

10.  Rat interferon inhibits steroid-inducible glycerol 3-phosphate dehydrogenase synthesis in a rat glial cell line.

Authors:  D Illinger; G Coupin; M Richards; P Poindron
Journal:  FEBS Lett       Date:  1976-05-01       Impact factor: 4.124
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  8 in total

1.  Local immunotherapy (beta-IFN) and systemic chemotherapy in primary glial tumors.

Authors:  A Boiardi; A Silvani; I Milanesi; L Munari; G Broggi; M Botturi
Journal:  Ital J Neurol Sci       Date:  1991-04

2.  Interferon inhibits the accumulation of glycerol phosphate dehydrogenase mRNA in oligodendrocytes and C6 cells.

Authors:  A C Passaquin; G Coupin; W A Schreier; P Poindron; R A Cole; J de Vellis
Journal:  Neurochem Res       Date:  1989-10       Impact factor: 3.996

3.  The effects of interferon on glial cells.

Authors:  M R Stratton; J M Martin; P L Lantos
Journal:  Br J Exp Pathol       Date:  1987-10

4.  Continuous human glioma-derived cell lines UC-11MG and UC-302MG. Morphologic, immunocytochemical and chromosomal characterization.

Authors:  B H Liwnicz; G Archer; S W Soukup; R G Liwnicz
Journal:  J Neurooncol       Date:  1986       Impact factor: 4.130

5.  Establishment of a human glioma cell line bearing a homogeneously staining chromosomal region and releasing alpha- and beta-type transforming growth factors.

Authors:  H Kanno; T Kuwabara; M Shinonaga; C C Chang; Y Tanaka; Y Sugio; H Morita; H Yasumitsu; M Umeda; Y Nagashima
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

6.  Products of cells from gliomas: IX. Evidence that two fundamentally different mechanisms change extracellular matrix expression by gliomas.

Authors:  P E McKeever; J Varani; S M Papadopoulos; M Wang; J P McCoy
Journal:  J Neurooncol       Date:  1995       Impact factor: 4.130

7.  Clinical effect of interferon in malignant brain tumours.

Authors:  M Nagai; T Arai
Journal:  Neurosurg Rev       Date:  1984       Impact factor: 3.042

8.  Sensitivities of human glioma cell lines to interferons and double-stranded RNAs individually and in synergistic combinations.

Authors:  R S Dick; H R Hubbell
Journal:  J Neurooncol       Date:  1987       Impact factor: 4.130
  8 in total

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